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IRCT20200421047160N2 IRCT 2023-05-07 Zanjan University of Medical Sciences The effect of oral Gabapentin and intravenous Dexamethasone on postoperative pain after hysterectomy comparision of the effect of oral Gabapentin compare to intravenous Dexamethasone on postoperative pain after elective hysterectomy 2023-04-04 anticipated 93 Complete https://irct.ir/trial/68462 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, block randomization will be used to allocate samples to intervention groups. In this method, blocks of 3 sizes are created, then so many blocks are selected to reach the required sample size in each group. Finally, 31 blocks of 3 will be created, Blinding description: The outcome assessor, who is a member of another department's staff, is unaware of the type of medication the patient received. Also, the statistical analyzer is not aware of the type of medicine received by the patient and all the samples have a code. 3 Pain intensity after hysterectomy surgery. Intervention 1: Intervention group: Half an hour before the start of surgery, 600 mg of oral gabapentin and intravenous placebo. Intervention 2: Intervention group: Half an hour before surgery, 8 mg of intravenous dexamethasone and oral placebo. Intervention 3: Control group: Half an hour before the surgery, both oral placebo and intravenous placebo. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Azadeh Hosseinkhani
Ansarieh St., 14 Valiasr St., Golestan, No. 1055, Unit 1
Zanjan Iran (Islamic Republic of) 4513622411 +98 24 3333 4261 azihsnkhani@zums.ac.ir Zanjan University of Medical Sciences scientific Neda Zamanpour
Koi Shahriar, 2 Baran Alley, Bahar 6 East, No. 44, 3rd floor
Zanjan Iran (Islamic Republic of) 4513622411 +98 24 3333 4261 Nedaz74@yahoo.com Zanjan University of Medical Sciences Iran (Islamic Republic of) Patient consent to participate in the study ASA class 1 or 2 Candidate for non-emergency abdominal hysterectomy surgery Hysterectomy for non-malignant reasons Lack of sensitivity to Gabapentin and Corticosteroids No history of chronic pain and neurological diseases Not receiving any kind of pain medication in the last 24 hours Not having diabetes and Hypertention 30 years 65 years Female Extending the duration of hysterectomy more than 3 hours Occurrence of any unusual complications during surgery Receiving pain medication during the operation Treatment - Drugs Treatment - Drugs Placebo Intervention group: Half an hour before the start of surgery, 600 mg of oral gabapentin and intravenous placebo Intervention group: Half an hour before surgery, 8 mg of intravenous dexamethasone and oral placebo Control group: Half an hour before the surgery, both oral placebo and intravenous placebo Pain score after hysterectomy. Timepoint: in hours 0 (recovery), 2, 6, 12, 24 after the operation. Method of measurement: Visual Analogue Scale. Determining the need for additional painkillers. Timepoint: in hours 0 (recovery), 1, 6, 12, and 24 hours after hysterectomy. Method of measurement: Patient request and registration in the medical record. The rate of side effects (nausea and vomiting, confusion and drowsiness, palpitations). Timepoint: in hours 0 (recovery), 1, 6, 12, and 24 hours after hysterectomy. Method of measurement: registration in the medical record. Zanjan University of Medical Sciences Approved 2023-02-12 Zanjan University of Medical Sciences Dr. Youssef Tashtobi Blvd, Zanjan University of Medical Sciences Zanjan Zanjan Iran (Islamic Republic of)