IRCT201211106415N2 IRCT 2013-01-02 Vice chancellor for research,Tehran University of Medical Sciences Effect of L-Arginine supplementation on antioxidant status in Pre-diabetic patients . Effect of L-Arginine supplementation on antioxidant enzyme activity of Type 2 Pre-diabetic patients 2012-10-31 anticipated 46 Complete https://irct.ir/trial/6850 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 2-3 pre-diabetic patient. Intervention 1: People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years. daily 3 g L-arginine (3 capsules containing 1 g L-arginine) was given every 8 hours for 8 weeks. At the end of the fourth and eighth weeks remaining capsules were counted, patients did not take their more than 10 percent of capsules, are excluded from the study. The subjects were told not to change diet and activity level. Intervention 2: People with pre-diabetes, a fasting blood sugar of 100 -125mg/ dL or a two-hour blood sugar between 140 to 199 mg/ dL - Range of BMI 25 to 34.9 Kg / m 2 - Age: 20 to 50 years. daily 3 g placebo(3 capsules containing 1 g Maltodextrin that was similar l-arginine) was given the same as the intervention group. The subjects were told not to change diet and activity level.