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IRCT20180712040448N2 IRCT 2023-06-01 Islamic Azad University Aliabad Katoul Branch The effect of physical exercises on TSH, GH, body composition indices and cognitive functions The effectiveness of resistance and aerobic trainings on serum levels of TSH and GH, body composition and cognitive functions indexes in adolescents 2023-05-22 anticipated 600 Complete https://irct.ir/trial/68503 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Participants were selected by stratified randommization and will be divided into research groups. Randomization Unit: Individual Randomization tool: Table of Morgan random numbers table The participants will be divided into boy and girl groups and then into active and inactive groups. Then they will be placed in the following groups: aerobic exercise, resistance exercise and control. N/A Condition 1: Examining changes in TSH hormone. Condition 2: Examining changes in GH hormone. Condition 3: Examining changes in body composition indices. Condition 4: Examining changes in cognitive function. Intervention 1: Intervention group: Resistance training: Each participant’s 6 repetition maximum (6 RM) will use to estimate their 1 RM using the Brzycki formula (%1RM = 102.78–2.78 * repetitions). This will use to determine the load corresponding to the prescribed intensity (% of 1RM) for the first week of training. The resistance training program will inform by accepted guidelines for resistance training in youth and involved a twice a week progressive periodized program including a variety of exercises for all major muscle groups using resistance machine exercises and free weights (bars and dumbbells), medicine balls, Bosu and Swiss balls. Participants perform between 2 and 4 sets of an exercise with between 30–120 seconds rest between sets. Overall, intensity will increase across the 16 weeks such that during weeks 1–5; 16–20 RM with 30 seconds rest between sets, in weeks 6–10; between 8–14 RM, with between 30–120 seconds inter-set rest, and in weeks 11–16; between 6 and 12 RM with 30–120 seconds inter-set rest. Intervention 2: Intervention group: Aerobic training: The intensity of the sessions was progressively will increase from moderate to vigorous across the course of the intervention. In order to determine the HR range which corresponded to the prescribed intensity, we will estimate maximum heart rate according to the Astrand’s formula (HR max = 216.6 –(0.84 x age)). Intensity and duration will progresse across the 16-week program as follows: weeks 1–3; 20 minutes at 65–75% of estimated max HR; weeks 4–6; 30 mins at 65–75%, weeks 7–12; 30 minutes at 70–80%, weeks 13–16; 35 minutes at 70–80%. The principal activities will use in aerobic are variations in straight line and multi directional jogging/running, with obstacles such as cones, hoops and speed ladders. Sessions also include step aerobics and sports orientated sessions incorporating balls. Intervention 3: Control group: They received no intervention without any lifestyle changes. Yes - There is a plan to make this available What will be shared: All information except statistical data; It can be shared after de-identifying the participants. When: The access period starts 6 months after the results are published To whom: Only for researchers working in academic and scientific institutions Conditions: Teaching how to sample, randomize, implement the protocol and use tools and tests Where to obtain: Dr. reza Rezaeeshirazi Dr.Rezaee@aliabadiau.ac.ir How to obtain: The applicant will receive the desired answer two weeks after submitting her/his application via email. Comments:
public Reza Rezaeeshirazi
Aliabad Katul City - University Blvd
Aliabad Katoul Iran (Islamic Republic of) 4941793451 +98 17 3422 2300 Dr.Rezaee@aliabadiau.ac.ir Islamic Azad University Aliabad Katoul Branch scientific Reza Rezaeeshirazi
Aliabad Katul City - University Blvd
Aliabad Katoul Iran (Islamic Republic of) 4941793451 +98 17 3422 2300 Dr.Rezaee@aliabadiau.ac.ir Islamic Azad University Aliabad Katoul Branch Iran (Islamic Republic of) Being between 11 and 15 years old Studying in one of the first secondary schools of Aliabad Katul city Consent of the family for their child's participation in the trial Ability to participate in physical exercises 11 years 15 years Both Taking a specific drug Suffering from specific physical or mental diseases Drug abuse lack of education E22.9 E22.9 E66.09 F99 Hyperfunction of pituitary gland, unspecified Hyperfunction of pituitary gland, unspecified Other obesity due to excess calories Mental disorder, not otherwise specified Lifestyle Lifestyle N/A Intervention group: Resistance training: Each participant’s 6 repetition maximum (6 RM) will use to estimate their 1 RM using the Brzycki formula (%1RM = 102.78–2.78 * repetitions). This will use to determine the load corresponding to the prescribed intensity (% of 1RM) for the first week of training. The resistance training program will inform by accepted guidelines for resistance training in youth and involved a twice a week progressive periodized program including a variety of exercises for all major muscle groups using resistance machine exercises and free weights (bars and dumbbells), medicine balls, Bosu and Swiss balls. Participants perform between 2 and 4 sets of an exercise with between 30–120 seconds rest between sets. Overall, intensity will increase across the 16 weeks such that during weeks 1–5; 16–20 RM with 30 seconds rest between sets, in weeks 6–10; between 8–14 RM, with between 30–120 seconds inter-set rest, and in weeks 11–16; between 6 and 12 RM with 30–120 seconds inter-set rest. Intervention group: Aerobic training: The intensity of the sessions was progressively will increase from moderate to vigorous across the course of the intervention. In order to determine the HR range which corresponded to the prescribed intensity, we will estimate maximum heart rate according to the Astrand’s formula (HR max = 216.6 –(0.84 x age)). Intensity and duration will progresse across the 16-week program as follows: weeks 1–3; 20 minutes at 65–75% of estimated max HR; weeks 4–6; 30 mins at 65–75%, weeks 7–12; 30 minutes at 70–80%, weeks 13–16; 35 minutes at 70–80%. The principal activities will use in aerobic are variations in straight line and multi directional jogging/running, with obstacles such as cones, hoops and speed ladders. Sessions also include step aerobics and sports orientated sessions incorporating balls. Control group: They received no intervention without any lifestyle changes. TSH blood levels. Timepoint: Measurement of TSH blood levels at the beginning of the second phase study (before the start of the intervention) and 16 weeks later. Method of measurement: laboratory kit. GH blood levels. Timepoint: Measurement of GH blood levels at the beginning of the second phase study (before the start of the intervention) and 16 weeks later. Method of measurement: laboratory kit. BMI. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: BMI Formula. Short term working memory. Timepoint: At the beginning of the first phase of the study, the beginning of the second phase of the study and its end. Method of measurement: digit span forward test. Amount of daily physical activity. Timepoint: At the beginning of the first phase of the study. Method of measurement: International Physical Activity Questionnaire (IPAQ) – Long Form. Body fat percentage. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Jackson-Pollock Formula. Lean body mass percentage. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Jackson Pollock's complementary formula. Processing speed. Timepoint: At the beginning of the first phase of the study, the beginning of the second phase of the study and its end. Method of measurement: digit-symbol coding test. Reaction time. Timepoint: At the beginning of the first phase of the study, the beginning of the second phase of the study and its end. Method of measurement: computer modified Stroop color-word test. Error number. Timepoint: At the beginning of the first phase of the study, the beginning of the second phase of the study and its end. Method of measurement: computer modified Stroop color-word test. Body fat mass. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: FM formula. Fat-free body mass. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: PFFM formula. Waist circumference. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: tape measure. Lipid profile. Timepoint: At the beginning of the second phase the study (before the start of the intervention) and 16 weeks later. Method of measurement: laboratory kit. Glucose. Timepoint: At the beginning of the second phase the study (before the start of the intervention) and 16 weeks later. Method of measurement: laboratory kit. Height. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: tape measure. Weight. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: digital Balance. Blood pressure. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: Sphygmomanometer. Muscle strength. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: 1 RM Formula. Aerobic power. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: submaximal treadmill test. Personality measurement. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Eysenck Eysenck Personality Questionnaire (JEPQ) Questionnaire (JEPQ). Academic motivation. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Harter's standard academic motivation questionnaire. Moods. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Brunel Mood Scale Questionnaire. General Health. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: General Health Questionare (GHQ-28). Internet Addiction. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Young's Internet Addiction Questionnaire. Appetite. Timepoint: At the beginning of the first phase of the study and its end. Method of measurement: Adolescent Food Habits Checklist (Johnson & et al). Complete Blood count (CBC). Timepoint: At the beginning of the second phase the study (before the start of the intervention) and 16 weeks later. Method of measurement: Fluorescece Flow Cytometry. Speed. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: 60 yard test. Legs explosive power. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: Sargent Jump Test. Hands explosive power. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: Medicine ball throw. Agility. Timepoint: At the beginning of the first phase of the study, at the beginning of the second phase of the study and its end. Method of measurement: T test. Islamic Azad University Aliabad Katoul Branch Approved 2023-01-08 Ethics committee of Islamic Azad University, Aliabad Katul Branch Aliabad Katul city - University Blvd - 4941793451 Aliabad Katul Golestan Iran (Islamic Republic of)