IRCT201107296420N6 IRCT 2011-08-21 Yazd research and clinical center for infertility Effect of growth hormone in IVF protocol Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology 2009-01-01 anticipated 120 Complete https://irct.ir/trial/6864 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 infertility. Intervention 1: In study group: Patients in group I (growth hormone group) receive daily injection of 4 mg growth hormone from day 21 of previous cycle until the day of hCG injection. Ovarian stimulation is started from second day of menstrual cycle with 300 IU of HMG monitoring by serial vaginal sonography and measurement of serum E2 levels. When dominant follicles reach to 14 mm in mean diameter, 0.25mg/day of GnRH antagonist(cetrotide) is started and continued until the day of hCG injection, when at least two follicles with a mean diameter of 17 mm were observed 10000 IU hCG is injected and oocyte retrieval is done 35 hours later. Intervention 2: In control group: Patients in group II (control group); Ovarian stimulation is started from second day of menstrual cycle with 300 IU of HMG monitoring by serial vaginal sonography and measurement of serum E2 levels is done. When dominant follicles reach to 14 mmin mean diameter, 0.25mg/day of GnRH antagonist (cetrotide , sereno) is started and continued until the day of hCG injection, when at least two follicles with a mean diameter of 17 mm were observed 10000 IU hCG was injected . and oocyte retrieval is done 35 hours later.