]>
IRCT201107306420N7 IRCT 2011-09-01 Yazd research and clinical center for infertility Transfer of Blastocysts in cryopreseved cycles Evaluation of pregnancy outcome after Transfer of Blastocysts derived from Frozen –Thawed cleavage stage embryos 2009-01-01 anticipated 150 Complete https://irct.ir/trial/6865 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this trial, 135 infertile women who were candidate for IVF or ICSI were informed about the research design and signed a written consent form. All women were randomly divided into two groups. Randomization was simple, individual using a random number table. N/A Infertility. Intervention 1: Intervention: Thawing is done at least 2 months after cryopreservation. All embryos in group 1 (blastocyst group) transfer to media and extended culture is done for 3 days until blastocyst development. Endometrial preparation is done by estradiol valerate consumption orally at the dose of 6 mg per day from the second day of menstrual cycle. In day13 of cycle, an ultrasound examination is performed. It is used to assess endometrial thickness. When the endometrial thickness reaches more than 8 mm in diameter, 100 mg progestron is injected daily. Transfer of embryos is done 3 days after thawing and thawing is done 2 days after progestron injection. Estradiol and progesterone consumption is continued until the documentation of fetal heart activity by ultrasound . Intervention 2: Control: Thawing is done at least 2 months after cryopreservation. All embryos in group 2 (cleavage group) are transfered to uterine cavity 2 hours after thawing. Endometrial preparation is done by estradiol valerate consumption orally at the dose of 6 mg per day from the second day of menstrual cycle. In day13 of cycle, an ultrasound examination is performed. It is used to assess endometrial thickness. When the endometrial thickness reaches more than 8 mm in diameter, 100 mg progestron is injected daily. Thawing is done 2 days after progestron injection. Estradiol and progesterone consumption is continued until the documentation of fetal heart activity by ultrasound. Yes - There is a plan to make this available What will be shared: All participant data sets are to be shared When: 2 months after the result publication To whom: A journal in which the results are published Conditions: Submission of an official application via the agent that is legally incharge Where to obtain: Yazd Reproductive Sciences Institute, Bouali Ave, Yazd, Iran. 983538247085 eftekharmaryam@yahoo.com How to obtain: 2 months after application Comments:
public Maryam Eftekhar
Bouali avenue , Safaieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 1824 7085 eftekhar@ssu.ac.ir YAazd Research and Clinical Center for Infertility scientific Maryam Eftekhar
Bouali avenue , Safaieh
Yazd Iran (Islamic Republic of) 8916877391 +98 35 1824 7085 eftekhar@ssu.ac.ir Yazd research and clinical center for infertility Iran (Islamic Republic of) women underwent previously in vitro fertilization (IVF) or intra-cytoplasmicsperm injection (ICSI) with embryo cryopreservation 20 years 35 years Female History of diabetes mellitus Thyroid disease Severe endometriosis Oocyte donation cycles Women with age>35 years Body mass index (BMI)>30 kg/m2 N98.9 Complication associated with artificial fertilization, unspecified Treatment - Other Treatment - Other Intervention: Thawing is done at least 2 months after cryopreservation. All embryos in group 1 (blastocyst group) transfer to media and extended culture is done for 3 days until blastocyst development. Endometrial preparation is done by estradiol valerate consumption orally at the dose of 6 mg per day from the second day of menstrual cycle. In day13 of cycle, an ultrasound examination is performed. It is used to assess endometrial thickness. When the endometrial thickness reaches more than 8 mm in diameter, 100 mg progestron is injected daily. Transfer of embryos is done 3 days after thawing and thawing is done 2 days after progestron injection. Estradiol and progesterone consumption is continued until the documentation of fetal heart activity by ultrasound . Control: Thawing is done at least 2 months after cryopreservation. All embryos in group 2 (cleavage group) are transfered to uterine cavity 2 hours after thawing. Endometrial preparation is done by estradiol valerate consumption orally at the dose of 6 mg per day from the second day of menstrual cycle. In day13 of cycle, an ultrasound examination is performed. It is used to assess endometrial thickness. When the endometrial thickness reaches more than 8 mm in diameter, 100 mg progestron is injected daily. Thawing is done 2 days after progestron injection. Estradiol and progesterone consumption is continued until the documentation of fetal heart activity by ultrasound. Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: Blood laboartory kit. Clinical pregnancy. Timepoint: 5 weeks after positive beta-hCG. Method of measurement: Observation of fetal heart activity by transvaginal ultrasonography. Ongoing pregnancy. Timepoint: 12 weeks after embryo transfer. Method of measurement: Ultrasonography. Miscarriage rate. Timepoint: Lost of pregnancy before 20 gestational week. Method of measurement: Absence of fetal heart activity in ultra sound sonography. Yazd research and clinical center for infertility Approved 2011-06-19 Yazd Research and Clinical Center for Infertility, Yazd University of Medical Sciences Safaeieh, Bouali Ave Yazd Yazd Iran (Islamic Republic of)