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IRCT20230205057334N1 IRCT 2023-09-10 Islamic Azad University Investigating the effect of zinc gluconate on sperm motility زینک گلوکونات یا zinc gluconate (ZG) Investigating changes in sperm motility and expression levels of Dazl, Pmca4 and Bcl2 genes in asthenospermic individuals under the influence of zinc gluconate (ZG) supplementation 2019-08-26 anticipated 40 Complete https://irct.ir/trial/68712 interventional Randomization: N/A, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Other design features: In this study, asthenospermic individuals referred to the infertility center were divided into two intervention groups 1 (control), which included asthenospermic individuals who consumed placebo for 90 days, and intervention group 2 (experimental), which included asthenospermic individuals who consumed zinc gluconate supplements for 90 days, Blinding description: This means that none of the patients know whether they have taken the drug or the placebo (the drug and the placebo were similar in terms of shape, color, and method of administration). The data analyst was also unaware of what the patients had consumed In the end, the spermogram information of each individual was only available to that person if necessary. The drug and placebo were similar in terms of shape, color, and method of administration, so blinding can be done at the participant level. 2 Asthenospermia. Intervention 1: Intervention group: 30 people with asthenospermia who received zinc gluconate supplement (from Simorgh Daru Company) at a dose of 30 mg daily for 90 days. Intervention 2: Control group: 30 people with asthenospermia who received placebo daily for 90 days. Undecided - It is not yet known if there will be a plan to make this available
public Kiandokht Koohestanian
11 Sayad St., No. 42, Unit 4
Mashhad Iran (Islamic Republic of) 9177735868 +98 935 972 7655 kian.dokht222@gmail.com Islamic Azad University scientific Kiandokht Koohestanian
11 Sayad St., No. 42, Unit 4
Mashhad Iran (Islamic Republic of) 9177735868 +98 935 972 7655 kian.dokht222@gmail.com Islamic Azad University Iran (Islamic Republic of) Infertile men, despite having at least one year of unprotected intercourse, natural fertility did not occur in their wives. All men were married and in the age range of 20 to 50 years. According to the expert's opinion and based on the WHO criteria, disorders related to asthenotaratospermia should have been observed in the sperm parameters of at least two samples of their sperm analysis with an interval of 2 weeks. 20 years 50 years Male single men People who had varicocele or other special disease and were diagnosed by a urologist and mentioned in their medical records. Men who had taken special medicine or drugs in the last three months. Infertile men who were not diagnosed by a neurogonadal specialist Participating in another study at the same time R86.9 Unspecified abnormal finding in specimens from male genital organs Treatment - Drugs Treatment - Drugs Intervention group: 30 people with asthenospermia who received zinc gluconate supplement (from Simorgh Daru Company) at a dose of 30 mg daily for 90 days. Control group: 30 people with asthenospermia who received placebo daily for 90 days. Sperm motility. Timepoint: In this study, the effect of zinc gluconate supplementation on sperm motility after 90 days of starting to take this supplement was performed on asthenospermic subjects. Method of measurement: spermogram reports of the patients . Mashhad Azad University Approved 2019-04-05 Ethics committee of mashhad azad university Mashhad, Sayad Shirazi Boulevard, Plate 42, Unit 4 mashhad Razavi Khorasan Iran (Islamic Republic of)