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IRCT20230106057067N1 IRCT 2023-03-19 Islamic Azad University Comparison of pain levels after abdominal surgery in patients receiving pregabalin and famotidine with pregabalin and diphenhydramine Comparison of pain levels after abdominal surgery in patients receiving pregabalin and famotidine with pregabalin and diphenhydramine in the hospitals of Islamic Azad University, Tehran Medical Branch in 2022 2022-03-21 anticipated 34 Complete https://irct.ir/trial/68730 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, first, a list of all patients who were willing to participate in the research was prepared, and after matching the patients who met the inclusion criteria, we assigned a number to each patient. We considered numbers 1 to 17 as group A and 18 to 34 as group B. Then, using an online random number table, the patients were placed in two groups (A group receiving pregabalin and famotidine and B group receiving pregabalin and diphenhydramine), Blinding description: Due to the double-blindness of this study, the drugs used for the patients were divided in A/B form by the head of the surgery department at the beginning of the study so that the researcher and the participants did not know the type of drug received. 2 Abdominal surgery. Intervention 1: One group received pregabalin and famotidine. The way to calculate the amount of drug and puff spray in patients was as follows: Famotidine 40 mg. Pregabalin 75 mg. Intervention 2: One group received pregabalin and diphenhydramine. The way to calculate the amount of medicine and puff spray in patients was as follows: weight less than or equal to 60 kg, one spoon of diphenhydramine syrup. Weight more than 60 kg, two spoons of diphenhydramine syrup. Pregabalin 75 mg. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Parnian Motamed Chabaki
Headquarters building of Tehran Islamic Azad University of Medical Sciences, corner of Gol Ikh St., Aineh Blvd., Amir Pabarja St., Doktor Shariati St., Doktor Shariati St., Tehran
Tehran Iran (Islamic Republic of) 1949635881 +98 912 074 3989 Parnianmotamed@gmail.com Islamic Azad University scientific Mahnaz Narimani Zamanabadi
Headquarters building of Tehran Islamic Azad University of Medical Sciences, corner of Gol Ikh St., Aineh Blvd., Amir Pabarja St., Doktor Shariati St., Doktor Shariati St., Tehran
Tehran Iran (Islamic Republic of) 1949635881 +98 912 146 9581 mahnaznarimani@gmail.com Islamic Azad University Iran (Islamic Republic of) Age 15-75 years old Informed and written consent ASA class 1 or 2 No abuse of drugs and alcohol Elective surgery 15 years 75 years Both Loss of consciousness Hemodynamic disorder Abnormal intraoperative bleeding Operation is more than 4 hours Treatment - Drugs Treatment - Drugs One group received pregabalin and famotidine. The way to calculate the amount of drug and puff spray in patients was as follows: Famotidine 40 mg. Pregabalin 75 mg One group received pregabalin and diphenhydramine. The way to calculate the amount of medicine and puff spray in patients was as follows: weight less than or equal to 60 kg, one spoon of diphenhydramine syrup. Weight more than 60 kg, two spoons of diphenhydramine syrup. Pregabalin 75 mg PAIN. Timepoint: After entering recovery and 24, 12, 6 hours after the operation. Method of measurement: Visual Analog Scale. Islamic Azad University Approved 2022-06-15 Ethics Committee of Tehran Islamic Azad University of Medical Sciences Headquarters building of Tehran Islamic Azad University of Medical Sciences, corner of Gol Ikh St., Aineh Blvd., Amir Pabarja St., Doktor Shariati St., Doktor Shariati St., Tehran Tehran Tehran Iran (Islamic Republic of)