IRCT20190717044255N7 IRCT 2023-02-25 Arak University of Medical Sciences effect of vitamin E on the prevention of acute renal injury in patients with leukemia The effect of vitamin E on the prevention of acute renal injury in patients with leukemia receiving vincristine 2023-03-25 anticipated 36 Complete https://irct.ir/trial/68773 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are placed in one of the intervention and control groups by random block allocation method with blocks of four. By assigning the letter A to the intervention group and the letter B to the control group, six states AABB, BBAA, BABA, ABBA, BAAB and ABAB are written on separate sheets and thrown into a container and randomly one of the sheets is taken out of the container and the composition written on it is noted and that sheet is thrown into the container again. Because the sample size in this study is 36 patients, this procedure is repeated 9 times and each time the combination written on each sheet is noted in the sequence of the order written on the previous sheet. Then, a number from 1 to 36 is assigned to each of the letters in the order of the letters noted one after the other, and each of the letters is placed in an envelope and the number of that letter is written on the envelope. Every time a disease is selected, one of the envelopes is opened according to the number written on the envelope and it is determined that the patient should be in the intervention or control group. 3 Leukemia. Intervention 1: Control group: In the control group, 18 patients received routine treatment with vincristine (Richter-Hungary) every week intravenously at a dose of 0.05 mg/kg for one month. During this period, patients will not receive any supplemental medicine containing vitamin E. Also, placebo medicine will not be used in this group. Intervention 2: Intervention group: In the intervention group, 18 patients with leukemia receive routine treatment with vincristine (Richter-Hungary) intravenously at a dose of 0.05 mg/kg every week. In addition, patients in the intervention group will receive one oral gelatin capsule of vitamin E, four hundred units (400 IU) (Dana Pharmaceuticals-Iran) for one month. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.