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IRCT20230202057305N1 IRCT 2023-03-03 Shahid Beheshti University of Medical Sciences Investigating the effect of furazolidone drug for the treatment of stomach bacterial infection no Comparison of efficacy and safety of quadruple regimens containing furazolidone in patients with Helicobacter pylori infection 2023-04-03 anticipated 135 Complete https://irct.ir/trial/68820 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: simple. Randomization unit: individual. Randomization tool: randomization using the site http://www.randomizer.0rg, which is extracted using random numbers obtained by the software, patients are divided into one of 3 groups: Amoxicillin A, Tetracycline T, and Levofloxacin L. In other words, We extract random numbers based on the number of samples introduced on the site, Blinding description: The patients were randomly selected and placed in groups that were unaware of the other groups, and the medication package was delivered to them in coded form. 2 H. pylori infection. Intervention 1: Intervention group: First intervention group: furazolidone, proton pump inhibitor, bismuth, amoxicillin. . which is in the form of furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, and amoxicillin 1000 every 12 hours and from Obeid Pharmaceutical Company for 10-14 days. Intervention 2: Intervention group: second intervention group: furazolidone, proton pump inhibitor, bismuth, tetracycline. Furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, tetracycline 500 every 6 hours. From Obeid Pharmaceutical Company for 10-14 days. Intervention 3: Intervention group: The third intervention group: furazolidone, proton pump inhibitor, bismuth, levofloxacin in the form of furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, and levofloxacin 500 daily from Obeid Pharmaceutical Company for 10-14 days. Yes - There is a plan to make this available What will be shared: All data can be shared after de-identification When: 6 months after the results are published To whom: public Conditions: Scientific and therapeutic research Where to obtain: Send your request to maryam.moghadam201@gmail.com How to obtain: Just submit your request in email maryam.moghadam201@gmial.com Comments:
public Seyed Maryam Moghadam Ziabari
Tabatabai St. - Stovar Alley - No. 5
Masal Iran (Islamic Republic of) 4381965747 +98 13 4468 2868 maryam.moghadam201@gmail.com Shahid Beheshti University of Medical Sciences scientific Seyed Maryam Moghadam Ziabri
Tabatabai St. - Stovar Alley - No. 5
Masal Iran (Islamic Republic of) 4381965747 +98 13 4468 2868 maryam.moghadam201@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Confirmation of H. pylori infection in patients by standard diagnostic methods Over seventeen years of age 17 years no limit Both History of known drug sensitivity to the studied drug regimen pregnancy Having chronic diseases (pulmonary, kidney, liver) Unwillingness to participate in the study Patients treated with other treatment methods such as probiotics, other antibiotics, etc. B96.81 Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: First intervention group: furazolidone, proton pump inhibitor, bismuth, amoxicillin. . which is in the form of furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, and amoxicillin 1000 every 12 hours and from Obeid Pharmaceutical Company for 10-14 days. Intervention group: second intervention group: furazolidone, proton pump inhibitor, bismuth, tetracycline. Furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, tetracycline 500 every 6 hours. From Obeid Pharmaceutical Company for 10-14 days Intervention group: The third intervention group: furazolidone, proton pump inhibitor, bismuth, levofloxacin in the form of furazolidone 100 every 12 hours, pentazol 40 every 12 hours, bismuth 240 every 12 hours, and levofloxacin 500 daily from Obeid Pharmaceutical Company for 10-14 days Eradication and safety of drug regimens containing furazolidone in patients with H. pylori infection. Timepoint: Investigating the eradication rate of H. pylori two weeks after the end of the treatment regimen. Method of measurement: Standard diagnostic methods include RUT, histology staining, bacterial culture, antigen test. H. pylori eradication, drug safety. Timepoint: Two weeks after the end of the eradication treatment. Method of measurement: Urea breath test, fecal antigen, bacterial culture, histology. Shahid Beheshti University of Medical Sciences Approved 2023-02-22 Ethics Committee of Shahid Beheshti Medical School Masal - Shahid Tabatabai St. - Stovar Alley - No. 5 Masal Guilan Iran (Islamic Republic of)