<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE trials [
<!ELEMENT trials (trial+)>

<!ELEMENT trial (main,contacts,countries,criteria,health_condition_code,health_condition_keyword,intervention_code,
          intervention_keyword,primary_outcome,secondary_outcome,secondary_sponsor,secondary_ids,source_support,ethics_reviews)>

<!ELEMENT main (trial_id,utrn?,reg_name,date_registration,primary_sponsor,public_title,acronym?,scientific_title,scientific_acronym?,
          date_enrolment,type_enrolment,target_size,recruitment_status,url?,study_type,study_design,phase,hc_freetext?,i_freetext?,results_actual_enrolment,results_date_completed,results_url_link,results_summary,           results_date_posted,results_date_first_publication,results_baseline_char,results_participant_flow,results_adverse_events,results_outcome_measures,results_url_protocol,results_IPD_plan, results_IPD_description)>
<!ELEMENT trial_id (#PCDATA)>
<!ELEMENT utrn (#PCDATA)>
<!ELEMENT reg_name (#PCDATA)>
<!ELEMENT date_registration (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT primary_sponsor (#PCDATA)>
<!ELEMENT public_title (#PCDATA)>
<!ELEMENT acronym (#PCDATA)>
<!ELEMENT scientific_title (#PCDATA)>
<!ELEMENT scientific_acronym (#PCDATA)>
<!ELEMENT date_enrolment (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT type_enrolment (#PCDATA)>
<!ELEMENT target_size (#PCDATA)>
<!ELEMENT recruitment_status (#PCDATA)><!-- Pending,Recruiting,Suspended,Complete,Other -->
<!ELEMENT url (#PCDATA)>
<!ELEMENT study_type (#PCDATA)><!-- interventional,observational -->
<!ELEMENT study_design (#PCDATA)>
<!ELEMENT phase (#PCDATA)>
<!ELEMENT hc_freetext (#PCDATA)>
<!ELEMENT i_freetext (#PCDATA)>
<!ELEMENT results_actual_enrolment (#PCDATA)>
<!ELEMENT results_date_completed (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_url_link (#PCDATA)>
<!ELEMENT results_summary (#PCDATA)>
<!ELEMENT results_date_posted (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_date_first_publication (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT results_baseline_char (#PCDATA)>
<!ELEMENT results_participant_flow (#PCDATA)>
<!ELEMENT results_adverse_events (#PCDATA)>
<!ELEMENT results_outcome_measures (#PCDATA)>
<!ELEMENT results_url_protocol (#PCDATA)>
<!ELEMENT results_IPD_plan (#PCDATA)>
<!ELEMENT results_IPD_description (#PCDATA)>


<!ELEMENT contacts (contact+)>
<!ELEMENT contact (type,firstname,middlename,lastname,address,city,country1,zip,telephone,email,affiliation)>
<!ELEMENT type (#PCDATA)><!-- Public,Scientific -->
<!ELEMENT firstname (#PCDATA)>
<!ELEMENT middlename (#PCDATA)>
<!ELEMENT lastname (#PCDATA)>
<!ELEMENT address (#PCDATA)>
<!ELEMENT city (#PCDATA)>
<!ELEMENT country1 (#PCDATA)>
<!ELEMENT zip (#PCDATA)>
<!ELEMENT telephone (#PCDATA)>
<!ELEMENT email (#PCDATA)>
<!ELEMENT affiliation (#PCDATA)>

<!ELEMENT countries (country2+)>
<!ELEMENT country2 (#PCDATA)>

<!ELEMENT criteria (inclusion_criteria,agemin,agemax,gender,exclusion_criteria)>
<!ELEMENT inclusion_criteria (#PCDATA)>
<!ELEMENT agemin (#PCDATA)>
<!ELEMENT agemax (#PCDATA)>
<!ELEMENT gender (#PCDATA)>
<!ELEMENT exclusion_criteria (#PCDATA)>

<!ELEMENT health_condition_code (hc_code+)>
<!ELEMENT hc_code (#PCDATA)>

<!ELEMENT health_condition_keyword (hc_keyword+)>
<!ELEMENT hc_keyword (#PCDATA)>

<!ELEMENT intervention_code (i_code+)>
<!ELEMENT i_code (#PCDATA)>

<!ELEMENT intervention_keyword (i_keyword+)>
<!ELEMENT i_keyword (#PCDATA)>

<!ELEMENT primary_outcome (prim_outcome+)>
<!ELEMENT prim_outcome (#PCDATA)>

<!ELEMENT secondary_outcome (sec_outcome+)>
<!ELEMENT sec_outcome (#PCDATA)>

<!ELEMENT secondary_sponsor (sponsor_name+)>
<!ELEMENT sponsor_name (#PCDATA)>

<!ELEMENT secondary_ids (secondary_id+)>
<!ELEMENT secondary_id (sec_id,issuing_authority)>
<!ELEMENT sec_id (#PCDATA)>
<!ELEMENT issuing_authority (#PCDATA)>

<!ELEMENT source_support (source_name+)>
<!ELEMENT source_name (#PCDATA)>

<!ELEMENT ethics_reviews (ethics_review+)>
<!ELEMENT ethics_review (status,approval_date,contact_name,contact_address,contact_phone,contact_email)>
<!ELEMENT status (#PCDATA)><!-- Not approved,Approved,NA -->
<!ELEMENT approval_date (#PCDATA)><!-- dd/mm/yyyy -->
<!ELEMENT contact_name (#PCDATA)>
<!ELEMENT contact_address (#PCDATA)>
<!ELEMENT contact_phone (#PCDATA)>
<!ELEMENT contact_email (#PCDATA)>
]>
<trials>
  <trial>
    <main>
      <trial_id>IRCT20230301057578N1</trial_id>
      <utrn></utrn>
      <reg_name>IRCT</reg_name>
      <date_registration>2023-03-04</date_registration>
      <primary_sponsor>university of neyshabur</primary_sponsor>
      <public_title>Effect of interval and intense resistance training on asprosin and CTRP1 levels in overweight and obese men</public_title>
      <acronym></acronym>
      <scientific_title>Effect of HIIT and intense resistance training on asprosin and CTRP1 levels in overweight and obese men</scientific_title>
      <scientific_acronym></scientific_acronym>
      <date_enrolment>2022-12-30</date_enrolment>
      <type_enrolment>anticipated</type_enrolment>
      <target_size>42</target_size>
      <recruitment_status>Complete</recruitment_status>
      <url>https://irct.ir/trial/68890</url>
      <study_type>interventional</study_type>
      <study_design>Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Simple random with code and lottery.</study_design>
      <phase>N/A</phase>
      <hc_freetext>Overweight and obesity.</hc_freetext>
      <i_freetext>Intervention 1: Intervention group: Intermittent training program for 10 weeks with a frequency of 3 days a week, including 4-8 times of running 20-30 seconds at maximum speed (intensity above 90-85% of the reserve heart rate) and with active rest intervals for 90 seconds (including running In intensity, it will be 40-50% of reserve heart rate. In the first and second weeks, the subjects will have four 20-second repetitions, and in the third and fourth weeks, following the principle of overload, they will do six 25-second attempts with the same rest time between repetitions, and in the fifth to last week, 8 repetitions. They will do 30 seconds with 90 seconds rest between repetitions. The intensity of the exercises will be controlled using a polar heart rate monitor. Before starting the training protocol in each session, subjects will have a 5-minute warm-up program and at the end of each training session, they will have a 5-minute cool-down program. Intervention 2: Intervention group: Subjects of the resistance training group performed leg press, chest press, back of thigh, front of thigh, forearm, back of arm, rowing and underarm pull-up with intensity of 80-85% of one maximum repetition in a circle 6-8 repetitions and 60 - 30 seconds of rest between each movement and 120 seconds of rest between each round of circles. In the first and second week, the number of three rounds and one round will be added every two weeks until it reaches six rounds in the eighth week. Before starting the training in each session, a warm-up program (10 minutes) and a cooling program (5 minutes) will be done at the end of each session. Intervention 3: Control group: This group does not do sports. Only basic measurements such as measuring anthropometric characteristics and blood sampling will be done.</i_freetext>
      <results_actual_enrolment></results_actual_enrolment>
      <results_date_completed></results_date_completed>
      <results_url_link></results_url_link>
      <results_summary></results_summary>
      <results_date_posted></results_date_posted>
      <results_date_first_publication></results_date_first_publication>
      <results_baseline_char></results_baseline_char>
      <results_participant_flow></results_participant_flow>
      <results_adverse_events></results_adverse_events>
      <results_outcome_measures></results_outcome_measures>
      <results_url_protocol></results_url_protocol>
      <results_IPD_plan>Undecided - It is not yet known if there will be a plan to make this available</results_IPD_plan>
      <results_IPD_description>Justification or reason for indecision in sharing IPD is There is no further information</results_IPD_description>
    </main>
    <contacts>
      <contact>
        <type>public</type>
        <firstname>Mehdi zarei</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Adib Blvd</address>
        <city>Neyshabur</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>9319774446</zip>
        <telephone>+98 51 4330 5653</telephone>
        <email>zarei.m8716@yahoo.com</email>
        <affiliation>University of Neyshabur</affiliation>
      </contact>
      <contact>
        <type>scientific</type>
        <firstname>Mehdi zarei</firstname>
        <middlename></middlename>
        <lastname></lastname>
        <address>Adib Blvd</address>
        <city>Neyshabur</city>
        <country1>Iran (Islamic Republic of)</country1>
        <zip>9319774446</zip>
        <telephone>+98 51 4330 5653</telephone>
        <email>zarei.m8716@yahoo.com</email>
        <affiliation>The University of Neyshabur</affiliation>
      </contact>
    </contacts>
    <countries>
      <country2>Iran (Islamic Republic of)</country2>
    </countries>
    <criteria>
      <inclusion_criteria>Body mass index above 25 kg/m2
Not having a physical injury and orthopedic problem
Not having regular sports activity in the last six months
No smoking and alcohol
Not taking medicine
Absence of cardiovascular diseases, diabetes, hypertension, liver disease, hypothyroidism</inclusion_criteria>
      <agemin>30 years</agemin>
      <agemax>50 years</agemax>
      <gender>Male</gender>
      <exclusion_criteria></exclusion_criteria>
    </criteria>
    <health_condition_code>
      <hc_code></hc_code>
    </health_condition_code>
    <health_condition_keyword>
      <hc_keyword></hc_keyword>
    </health_condition_keyword>
    <intervention_code>
      <i_code>Rehabilitation</i_code>
      <i_code>Rehabilitation</i_code>
      <i_code>Other</i_code>
    </intervention_code>
    <intervention_keyword>
      <i_keyword>Intervention group: Intermittent training program for 10 weeks with a frequency of 3 days a week, including 4-8 times of running 20-30 seconds at maximum speed (intensity above 90-85% of the reserve heart rate) and with active rest intervals for 90 seconds (including running In intensity, it will be 40-50% of reserve heart rate. In the first and second weeks, the subjects will have four 20-second repetitions, and in the third and fourth weeks, following the principle of overload, they will do six 25-second attempts with the same rest time between repetitions, and in the fifth to last week, 8 repetitions. They will do 30 seconds with 90 seconds rest between repetitions. The intensity of the exercises will be controlled using a polar heart rate monitor. Before starting the training protocol in each session, subjects will have a 5-minute warm-up program and at the end of each training session, they will have a 5-minute cool-down program.</i_keyword>
      <i_keyword>Intervention group: Subjects of the resistance training group performed leg press, chest press, back of thigh, front of thigh, forearm, back of arm, rowing and underarm pull-up with intensity of 80-85% of one maximum repetition in a circle 6-8 repetitions and 60 - 30 seconds of rest between each movement and 120 seconds of rest between each round of circles. In the first and second week, the number of three rounds and one round will be added every two weeks until it reaches six rounds in the eighth week. Before starting the training in each session, a warm-up program (10 minutes) and a cooling program (5 minutes) will be done at the end of each session.</i_keyword>
      <i_keyword>Control group: This group does not do sports. Only basic measurements such as measuring anthropometric characteristics and blood sampling will be done.</i_keyword>
    </intervention_keyword>
    <primary_outcome>
      <prim_outcome>Asprosin. Timepoint: the beginning of the study and 48 hours after the end of the training period (in the fasting state). Method of measurement: Blood sampling and checking of serum levels. ELISA kit will be used.</prim_outcome>
      <prim_outcome>CTRP1. Timepoint: the beginning of the study and 48 hours after the end of the training period (in the fasting state). Method of measurement: Blood sampling and checking of serum levels. ELISA kit will be used.</prim_outcome>
    </primary_outcome>
    <secondary_outcome>
      <sec_outcome></sec_outcome>
    </secondary_outcome>
    <secondary_sponsor>
      <sponsor_name></sponsor_name>
    </secondary_sponsor>
    <secondary_ids>
      <secondary_id>
        <sec_id></sec_id>
        <issuing_authority></issuing_authority>
      </secondary_id>
    </secondary_ids>
    <source_support>
      <source_name>university of neyshabur</source_name>
    </source_support>
    <ethics_reviews>
      <ethics_review>
        <status>Approved</status>
        <approval_date>2023-02-24</approval_date>
        <contact_name>University of Zabul (Research Ethics Committee)</contact_name>
        <contact_address>Campus address 1: Zabul-km two Banjar road campus address zabol Sistan-va-Balouchestan Iran (Islamic Republic of)</contact_address>
        <contact_phone></contact_phone>
        <contact_email></contact_email>
      </ethics_review>
    </ethics_reviews>
  </trial>
</trials>
