IRCT20221212056796N1 IRCT 2023-04-15 Arak University of Medical Sciences The analgesic efficacy of lidocaine/prilocaine cream during fine-needle aspiration biopsy of thyroid nodules The analgesic efficacy of lidocaine/prilocaine cream during fine-needle aspiration biopsy of thyroid nodules 2023-04-21 anticipated 80 Complete https://irct.ir/trial/69039 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study, the permutation random block method will be used for randomization. For this purpose, a block of 6 will be used. In each block, the letter L (Lidocaine) is written on three cards, and the letter P (Placebo) is also written on three cards and is placed in a sealed envelope, the envelopes are selected randomly by Simple random sampling. The random blocks of 6 selected are as follows: PLPLLP, PPLPLL, LPPLLP, PLPLPL, LPPLLP, LPLLPP, PLLLPP, LPPLLP, PLLPPL, PPLPLL, LPLLPP, LLPLPP, LPPLLP. For example, the method of random allocation in the PLPLLP block of 6 is as follows: the first patient is assigned to treatment P, the second patient is assigned to treatment L, the third patient is assigned to treatment P, the fourth patient is assigned to treatment L, the fifth patient is assigned to treatment L, and the sixth patient is assigned to treatment P randomly, Blinding description: The supervisor who is the main researcher, is responsible for giving different creams and she is not blind. A specialist clinical assistant is responsible for pain assessment and FNA procedure and he is blind. Information about the grouping of patients is not provided to the statistical analyst of the data and the study. The participants are fully informed about the procedure and the fact that they could be subject to treatment by analgesic cream or placebo cream. However, they are not aware of the type of cream used for them and this information is hidden from them. 3 Thyroid nodules. Intervention 1: Intervention group: Lidocaine + prilocaine 5% local anesthetic cream of Tehran Chemical Pharmaceuticals in the amount of 2.5 ml (~2.5 grams) will be used uniformly in a thick layer on the biopsy site of the nodule 60 minutes before the procedure. Intervention 2: Control group: Placebo cream consists of a white lotion (containing lubricant 5 g and Oserin 150 g) that looks like lidocaine/prilocaine cream. An amount of 2.5 ml (~2.5 g) will be used uniformly in a thick layer on the biopsy site of the nodule 60 minutes before the procedure. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is According to the ownership of the data by the research center of the hospital, no decision has been taken at this time and there is no more information.