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IRCT20230305057631N1 IRCT 2023-05-24 Gonabad University of Medical Sciences Association of response to doxycycline and Azithromycin antibiotics therapy and IL-4 gene ( SR8179190) polymorphism in patients with moderate acne vulgaris Association of response to doxycycline and Azithromycin antibiotics therapy and IL-4 gene ( SR8179190) polymorphism in patients with moderate acne vulgaris 2023-03-13 anticipated 54 Complete https://irct.ir/trial/69056 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization, at first, the people who meet the criteria to enter the study will be selected to participate in the study based on their consent, and then the people will be divided into two intervention groups in the form of block allocation. In order to assign patients to two treatment groups, the Blocked Randomization method with blocks of four will be used. First, six possible states of blocks (BAAB, ABBA, BABA, BBAA, ABAB, AABB) are listed and a number from one to six is assigned to each block. Then, numbers between one and six are randomly selected using a table of random numbers, and then people are assigned to the azithromycin (A) and doxycycline (B) group based on the block corresponding to the selected number, and this work is done until completion. The sample size will continue. 2 Acne vulgaris. Intervention 1: Intervention group: At first, the patients were examined by a dermatologist and the severity of their acne was measured based on the Michelson acne score, and the patients were subjected to standard photography. Next, the patients are divided into two groups. The first group receives doxycycline 100 mg daily along with topical treatment (benzoyl peroxide and tretinoin). Intervention 2: Intervention group: At first, the patients were examined by a dermatologist and the severity of their acne was measured based on the Michelson acne score, and the patients were subjected to standard photography. Next, the patients are divided into two groups. The second group receives 250 mg of azithromycin every other day along with topical treatment (benzoyl peroxide and tretinoin). Yes - There is a plan to make this available What will be shared: All the data will be provided to the researchers without names and specifications. When: After completing the research project and publishing the article To whom: All researchers Conditions: To conduct similar research, researchers can access the results of the project by referring to the research assistant of Gonabad University of Medical Sciences with a written consent letter from the research assistant. Where to obtain: Research assistant of Gonabad University How to obtain: Researchers can have access to the results of the project by referring to the vice president of research of Gonabad University of Medical Sciences with a written consent letter from the vice president of research. Comments:
public Hamide Mohammadzadeh
Bohlool hospital, Parastar Blvd.
Gonabad Iran (Islamic Republic of) 96917-97852 +98 51 5723 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences scientific Hamide Mohammadzadeh
Bohlool hospital, Parastar Blvd.
gonabad Iran (Islamic Republic of) 96917-97852 +98 51 5728 6832 Mohammadzadeh.hamideh@yahoo.com Gonabad University of Medical Sciences Iran (Islamic Republic of) Acne vulgaris with moderate severity according to the classification system (MAS score) Acne vulgaris with moderate severity according to vaishampayan classification system Age over 12 years 12 years no limit Both Failure to complete the treatment process by the patient Occurrence of unusual complications during treatment The patient's refusal to continue the treatment process L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: At first, the patients were examined by a dermatologist and the severity of their acne was measured based on the Michelson acne score, and the patients were subjected to standard photography. Next, the patients are divided into two groups. The first group receives doxycycline 100 mg daily along with topical treatment (benzoyl peroxide and tretinoin). Intervention group: At first, the patients were examined by a dermatologist and the severity of their acne was measured based on the Michelson acne score, and the patients were subjected to standard photography. Next, the patients are divided into two groups. The second group receives 250 mg of azithromycin every other day along with topical treatment (benzoyl peroxide and tretinoin). Response to treatment. Timepoint: Before starting the treatment, after the end of the treatment. Method of measurement: MAS score. Satisfaction level. Timepoint: Before starting the treatment, after the end of the treatment. Method of measurement: check list. Recovery from the doctor's opinion. Timepoint: Before starting the treatment, after the end of the treatment. Method of measurement: Check list. Gonabad University of Medical Sciences Approved 2023-01-24 Gonabad University of Medical Sciences Gonabad University of Medical Sciences, near Asabi Road Gonabad Razavi Khorasan Iran (Islamic Republic of)