]>

IRCT20180103038199N14 IRCT 2023-03-14 Mashhad University of Medical Sciences Investigating the effect of carrot seed capsules on the sexual desire of female patients with multiple sclerosis Investigating the effect of carrot (Daucus carota) seed capsules on the sexual desire of female patients with multiple sclerosis 2023-04-21 anticipated 40 Recruiting https://irct.ir/trial/69083 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The blocked randomization method is used. The volume of each block will be four. Then the list of blocks is written and numbers assigned to them, for example (AABB(1)- BBAA(2)- BABA(3)- BAAB(4)), which will be 10 blocks according to the sample size of 40. Then random numbers between 1 and 10 are selected according to the randomization site Randomaization.com and finally, the treatment allocation list is determined based on the random numbers, Blinding description: Using sealed envelopes Due to the use of a placebo similar to the intervention treatment, the investigator and the participants will not be informed of the assigned treatment, and the analyst will also be unaware of the assigned treatment for the two groups. Finally, after analyzing the data, the researcher who prepared the packages will reveal codes A and B. 2 Women suffering from multiple sclerosis complaining of lack or absence of sexual desire. Intervention 1: Intervention group: Women suffering from multiple sclerosis with complaints of lack or absence of sexual desire use 500 mg capsules containing carrot seed powder 3 times a day for 12 weeks. Intervention 2: Control group: Women suffering from multiple sclerosis with complaints of lack or absence of sexual desire use 500 mg placebo capsules similar to carrot seed capsules 3 times a day for 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available

public Dr. Vahid Reza Askari

Faculty of medicine, Paradise of University, Vakil-Abad Blvd., Azadi Sq., Mashhad

Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2264 askariv@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Vahid Reza Askari

Faculty of medicine, Paradise of University, Vakil-Abad Blvd., Azadi Sq., Mashhad

Mashhad Iran (Islamic Republic of) 9177948564 +98 51 3800 2264 askariv@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Married women with multiple sclerosis Age between 18-45 With complaints of lack or absence of sexual desire More than 6 months have passed since their marriage Normal pelvic examination findings Have a normal pap smear in the last 3 years Have access to having sex with a partner monthly for at least 15 days 18 years 45 years Female Pregnancy or breastfeeding Menopause Any disability or serious medical problem that requires constant care and treatment Suffering from major depressive disorder and other psychiatric disorders Husband's sexual problems Divorce F52.0 Hypoactive sexual desire disorder Treatment - Drugs Placebo Intervention group: Women suffering from multiple sclerosis with complaints of lack or absence of sexual desire use 500 mg capsules containing carrot seed powder 3 times a day for 12 weeks. Control group: Women suffering from multiple sclerosis with complaints of lack or absence of sexual desire use 500 mg placebo capsules similar to carrot seed capsules 3 times a day for 12 weeks. Overall score of the FSFI questionnaire. Timepoint: At the beginning of the study and then every 4 weeks until week 12. Method of measurement: FSFI Questionnaire. Fatigue rate. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: MFIS fatigue assessment questionnaire. The level of anxiety and depression. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Spielberger anxiety questionnaire. LH levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. FSH levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. Prolactin levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. Testosterone levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. CBC diff levels. Timepoint: At the beginning of the study and after 6 and 12 weeks of treatment. Method of measurement: Laboratory kit. Interleukin-6 levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. TNF-a levels. Timepoint: At the beginning of the study and after 12 weeks of treatment. Method of measurement: Laboratory kit. Mashhad University of Medical Sciences Approved 2022-09-06 Research Ethics Committees of School of Medicine- Mashhad University of Medical Sciences School of medicine, Paradise of University, Vakil-Abad Blvd., Azadi Sq., Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)