IRCT20190117042390N2 IRCT 2023-10-12 Rafsanjan University of Medical Sciences Compare effects propofol and dexmedetomidine in hemodynamic Changes and delirium in trauma patients in the ICU of Ali Ebn Abitaleb Hospital of Rafsanjani years 2023 Compare effects propofol and dexmedetomidine in hemodynamic Changes and delirium in trauma patients in the ICU 2022-09-16 anticipated 40 Complete https://irct.ir/trial/69538 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Crossover, Purpose: Treatment, Other design features: And the exclusion criteria include patients with unstable hemodynamics and drug sensitivity to propofol (due to the possibility of delayed seizures, the patient should be cared for until one day after the operation) as well as patients with a history of drug abuse, drug abuse, or Dependence on alcohol, history of neurological, neuromuscular or psychiatric diseases, especially history of seizures or epilepsy, history of pulmonary and cardiovascular diseases, long-term and chronic use of pain relievers including cyclooxygenase 2 inhibitors are also excluded from the study. used in This research consists of: 1- Propofol with the brand name Pofol (it is a drug that is used by short-acting intravenous injection method and causes a decrease in the level of consciousness or anesthesia. This drug is used to start anesthesia and also maintain anesthesia during surgery. and in the form of 20ml ampoules containing 1% propofol. Due to the use of emulsion, soy and egg, a history of sensitivity to these substances can indicate sensitivity to propofol. 2- Dexmedetomidine, which is a sedative drug and is used in patients who are carefully are under medical care and require mechanical ventilation. Dexmedetomidine is administered as a slow intravenous injection by the medical staff using a slow drug injection device, and it contains 200 mg of dexmedetomidine in ampoules of 20 ml, Randomization description: Sampling was simple random and until the completion of the sample size among eligible clients. Then, the samples are divided into two similar groups of 20 people, dexmedetomidine and propofol, using the table of random numbers. And they are divided into two groups D and P and they are placed in one of the two groups according to the order of entry into the study (even and odd), Blinding description: There are 40 trauma patients with an age range of 18-55 years. The study subjects will be divided into two groups of 20 people receiving dexmedetomidine and propofol, and hemodynamic changes and delirium will be investigated. 4 Condition 1: head trauma patients. Condition 2: thorax trouma. Intervention group:Two groups of 20 people receiving dexmedetomidine and propofol. Yes - There is a plan to make this available What will be shared: If the request is received, the desired information will be sent via email When: Up to one year after publication To whom: hamid pakzad Conditions: If there is a request from official sources to use new research in line with the topic under study Where to obtain: Send to the responsible author's email How to obtain: Sending to email, checking and verifying the test and resending to the requester Comments: