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IRCT20150606022569N4 IRCT 2023-10-26 Bojnourd University of Medical Sciences The effectiveness of DHA serum in the treatment of aluminum phosphide poisoning Determining the effectiveness of Dihydroxyacetone (DHA) serum in the treatment of patients with aluminum phosphide (rice tablet) poisoning by assessing the blood pressure and ECG changes and cardiac function 2023-11-05 anticipated 10 Complete https://irct.ir/trial/69575 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment, Other design features: A Prospective Pre-Post Study. 2 Poisoning with rice tablets (aluminum phosphide). Intervention group: The dihydroxyacetone (DHA) serum for injection, which is prepared in 500 cc bottles of 5% dextrose water at Shiraz University of Medical Sciences, is given intravenously to the patient who meets the inclusion criteria at a rate of 500 cc (one bottle) per hour. If the patient tolerates it and there are no life-threatening complications, the second and third 500 cc are administered. If needed, up to the maximum total volume of 2500 cc is infused for them.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Mohammad Bagher Oghazian
Dolat Blvd., Central Building of North Khorasan University of Medical Sciences, Bojnurd
Bojnurd Iran (Islamic Republic of) 9414974877 +98 58 3151 0000 mohammadbagher_oghazian@yahoo.com Bojnourd University of Medical Sciences scientific Leila Hosseini
Dolat Blvd., Central Building of North Khorasan University of Medical Sciences, Bojnurd
Bojnurd Iran (Islamic Republic of) 9414974877 +98 58 3151 0000 Hosseini1115@yahoo.com Bojnourd University of Medical Sciences Iran (Islamic Republic of) This study is conducted on people who have been poisoned (intentionally or unintentionally) with aluminum phosphide (rice tablets). no limit no limit Both The rice tablet(s) is/are exceeded their expiration date. The tablet(s) is/are exposed to moisture and release(s) its/their phosphine gas. The tablet(s) is/are dissolved in water prior to use and so release(s) its/their phosphine gas. The tablet(s) is/are thoroughly crushed before use, resulting in a large amount of phosphine gas being released. The tablet(s) and its/their contents are thrown out immediately after eating due to vomiting. The person ingested the "Banan tablet" (a tablet that contains garlic, salt and starch, and is sometimes erroneously referred to as the rice tablet in Iran). T60.4 Toxic effect of rodenticides Treatment - Drugs Intervention group: The dihydroxyacetone (DHA) serum for injection, which is prepared in 500 cc bottles of 5% dextrose water at Shiraz University of Medical Sciences, is given intravenously to the patient who meets the inclusion criteria at a rate of 500 cc (one bottle) per hour. If the patient tolerates it and there are no life-threatening complications, the second and third 500 cc are administered. If needed, up to the maximum total volume of 2500 cc is infused for them. Changes in blood pressure. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Blood pressure monitor. Electrocardiogram (ECG) changes. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Electrocardiography. Contractile strength of the heart by measuring EF. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Echocardiography. Arterial oxygen saturation. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Measurement of arterial oxygen saturation. Blood glucose. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Laboratory measurement of blood glucose. Level of consciousness. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Using the Glasgow Coma Scale (GCS). Mortality rate. Timepoint: End of the study. Method of measurement: Number of patients who died. Incidence of adverse effects. Timepoint: During and following the administration of DHA until the death or hospital discharge. Method of measurement: Incidence of the adverse effect following DHA injection. Arterial blood acidity. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Measurement of arterial blood pH. Heart rate. Timepoint: At predetermined intervals prior to and following the administration of DHA until the death or hospital discharge. Method of measurement: Heart rate monitor. Shiraz University of Medical Sciences Bojnourd University of Medical Sciences Hossein Niknahad Approved 2022-05-22 North Khorasan University of Medical Sciences Dolat Blvd., Central Building of North Khorasan University of Medical Sciences, Bojnurd Bojnurd North Khorasan Iran (Islamic Republic of)