IRCT20151227025726N34 IRCT 2023-10-09 Shahid Beheshti University of Medical Sciences Evaluating the effects of saffron on fatigue symptoms in patients with chronic obstructive pulmonary disease Evaluating the Effects of Crocus Sativus herbal product on Chronic Fatigue Syndrome in Patients with Chronic Obstructive Pulmonary Disease 2023-10-12 anticipated 70 Complete https://irct.ir/trial/69608 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, block randomization method is used. Thirty five block including 2 patients generated with the help of the online website (www.sealedenvelope.com/simple-randomiser/v1/lists). In each block, one patient is assigned to the crocus sativus group and one patient to the control group, Blinding description: Patients included to the study are randomized to two groups of drug and control (crocus sativus and placebo) by a randomizer according to the randomization list taken from www.sealedenvelope.com. The researcher and data analyst only receive the data in code and were not aware of patients' assignments to the two groups. 3 Chronic obstructive pulmonary disease. Intervention 1: Intervention group: Patients in the intervention group received capsules containing 30 mg of dry saffron extract (Duralife® prepared by Faran Shimi Company) twice a day for two months. Intervention 2: Control group: Patients in the control group received placebo capsules prepared by Faran Shimi Company twice a day for two months. Yes - There is a plan to make this available What will be shared: All potential data can be shared after blinding. When: Six months after publishing the results To whom: Researchers working in academic institutions Conditions: For research purposes and meta-analysis studies Where to obtain: Dr. farzaneh Dastan, Dr. Masih Daneshvari Hospital, Daar-Abad, Niavaran How to obtain: Official letter to the researchers through Email (fzh.dastan@gmail.com) Comments: