IRCT20170105031787N6 IRCT 2023-05-03 Iran University of Medical Sciences Two very low doses of naloxone in combination with ropivacaine on the onset ,severity and duration of axillary block Comparison of two very low doses of naloxone in combination with ropivacaine on the onset ,severity and duration of axillary block in patients with hand and forearm surgery 2023-05-22 anticipated 60 Complete https://irct.ir/trial/69713 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into 3 groups. The randomization tool will be a random sequence generation software called SIS. In addition to simple randomization, these random sequence generation softwares are capable of generating random sequences using the block method. Block randomization method will be used for randomization. Block randomization is for the purpose of making sure that exactly equal number of participants enter the study groups. The advantages of block randomization are that the balance of the number of participants in each group is guaranteed. For this purpose, 6 blocks will be formed and in each block 2 people from intervention group 1, 2 people from intervention group 2 and 2 people will be placed in the control group. A total of 10 blocks will be considered to reach the sample size. Random allocation concealment will be done using opaque envelopes sealed with a random sequence, in this method, each of the random sequences created is recorded on a card and the cards are placed inside the envelopes in order. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the letter envelopes are glued and placed in a box, respectively. the door At the beginning of the registration of participants, based on the order of entry of eligible participants into the study, one of the envelopes of the letter is opened in order and the assigned group of the participant is revealed, Blinding description: The surgeon and the patients will be unaware and blind of the type of drug used in the axillary block. To hide similar and identical sera, it was used without drug name label and only with code. Patients will be aware that they will be randomly assigned to one of three treatment groups, but will not know which treatment will be provided in that group. Patients will be assigned to one of three groups using a random number table. The surgeon also knows that axillary block will be performed by three different methods for the patients, but he will not know which method will be performed for each patient. The person in charge of data collection, the analyst, and the outcome evaluator will collect and analyze the information based on groups 1, 2, and 3, and will not know the type of treatment provided in the groups and will be kept blind. 3 hand and forearm surgery. Intervention 1: Intervention group 1: The axillary block will be performed using 29 cc of ropivacaine 0.5% (manufacturer: Varian Pharmamed) plus 1 cc of naloxone 4 micrograms (manufacturer: Tolid Daroo). Intervention 2: Intervention group 2: The axillary block will be performed using 29 cc of ropivacaine 0.5% (manufacturer: Varian Pharmamed) plus 1 cc of naloxone 0.4 micrograms (manufacturer: Tolid Daroo). Intervention 3: Control group: The axillary block will be performed using 29 cc of ropivacaine 0.5% (manufacturer: Varian Pharmamed) plus 1 cc of normal saline (30 cc in total). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After completing the work and consulting with all the writers and executive agents, I will be decided.