IRCT20200825048515N68 IRCT 2023-06-14 Esfahan University of Medical Sciences The effect of lidocaine and ketamine on pain after upper limb orthopedic surgery Investigating the preventive effect of lidocaine infusion and ketamine infusion on pain after upper limb orthopedic surgery under general anesthesia 2023-07-21 anticipated 180 Complete https://irct.ir/trial/69716 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, 180 eligible patients are randomly selected. Then the letters A, B and C are written on 60 sheets and each one is placed in an envelope. Each patient is then asked to choose one of the envelopes. Depending on the selected envelope, the patient is assigned to one of three groups, Blinding description: In order to achieve the triple-blind study, two drugs lidocaine and ketamine as well as placebo will be prepared daily by the operating room nurse (without the knowledge of the researcher) in the same syringes and labeled as A, B, C, and D. And is given daily to the anesthesiologist (researcher). Therefore, the patient, the Investigator, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention. 3 Upper extremity orthopedic surgery. Intervention 1: First intervention group: patients in this group will be injected with lidocaine infusion at a low dose (1 mg/kg/hour) at the end of the operation. Intervention 2: Second intervention group: patients in this group, at the end of the operation, are given intravenous ketamine infusion at a dose (0.25 mg per kilogram of body). Intervention 3: Control group: patients in this group will be injected with normal saline infusion. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information