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IRCT20221120056548N11 IRCT 2023-08-08 Vice President of Research at Danesh Alborz University The effect of exercise and artichoke extract on non-alcoholic fatty liver The effect of eight weeks of high intensity interval training (HIIT), resistance training and consumption of artichoke extract on the level of sirtuin 1 and team enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in patients with non-alcoholic fatty liver disease 2023-08-11 anticipated 60 Complete https://irct.ir/trial/69765 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: In this randomization, the method of equal blocks (15 blocks of 4) has been used, in which a number of intervention people and a number of comparison people are included in each block, and we have allocated them to different groups. The method and tool of block random sequence generation has been done using https://www.sealedenvelope.com/simple-randomiser/v1/lists. N/A Non-alcoholic fatty liver. Intervention 1: Intervention group: Intense interval training was performed for 8 weeks and four sessions per week and each session lasted for 60 minutes (15 minutes of warm-up + 30 minutes of interval training + 15 minutes of cooling) with an intensity of 80-85% of the maximum heart rate. They performed high-intensity resistance training of 7 movements 3 times a week. In the first two weeks, they did one maximum repetition and 6 repetitions with 90% intensity, in the third to fifth week with 95% maximum repetition and 4 repetitions, and the last three weeks with 100% ability and two repetitions. The amount of rest between sets was 1 minute and between stations was 2 to 3 minutes. For each subject in each station, which included barbell chest press, front shoulder with barbell, front underarm lat, front arm with cable hand, back arm with cable, front thigh with machine and back thigh with machine, the amount of weight It was found that it is usually able to lift less than 10 times. Artichoke extract is consumed in the following way. The parts of this plant were dried in the shade and crushed with the help of a grinder and turned into powder. The chopped leaves of the dried artichoke plant (fluffy silver leaves) were given to the study subjects in the form of packages in the required number, and they were asked to take them for 45 days, in two occasions (at night before going to bed; that is, two hours after eating dinner and the second time in the morning fasting one hour before breakfast) brew a tablespoon of plant leaves with a glass of boiling water for 20 minutes on indirect heat and at a temperature of 80 degrees Celsius. Intervention 2: Control group: This group is not subjected to any exercise intervention and supplement consumption. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 6 months after the results are published To whom: It will be available for researchers working in academic and scientific institutions. Conditions: If the intellectual rights are preserved, the data can be sent to the researchers. Where to obtain: Email address: saeidshamlou9092@gmail.com How to obtain: Submission of a written request (one week) Comments:
public Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University scientific Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University Iran (Islamic Republic of) Non-alcoholic fatty liver disease being menopausal 50 years 65 years Female History of cardiovascular disease K76.0 Fatty (change of) liver, not elsewhere classified Treatment - Other Treatment - Other Intervention group: Intense interval training was performed for 8 weeks and four sessions per week and each session lasted for 60 minutes (15 minutes of warm-up + 30 minutes of interval training + 15 minutes of cooling) with an intensity of 80-85% of the maximum heart rate. They performed high-intensity resistance training of 7 movements 3 times a week. In the first two weeks, they did one maximum repetition and 6 repetitions with 90% intensity, in the third to fifth week with 95% maximum repetition and 4 repetitions, and the last three weeks with 100% ability and two repetitions. The amount of rest between sets was 1 minute and between stations was 2 to 3 minutes. For each subject in each station, which included barbell chest press, front shoulder with barbell, front underarm lat, front arm with cable hand, back arm with cable, front thigh with machine and back thigh with machine, the amount of weight It was found that it is usually able to lift less than 10 times. Artichoke extract is consumed in the following way. The parts of this plant were dried in the shade and crushed with the help of a grinder and turned into powder. The chopped leaves of the dried artichoke plant (fluffy silver leaves) were given to the study subjects in the form of packages in the required number, and they were asked to take them for 45 days, in two occasions (at night before going to bed; that is, two hours after eating dinner and the second time in the morning fasting one hour before breakfast) brew a tablespoon of plant leaves with a glass of boiling water for 20 minutes on indirect heat and at a temperature of 80 degrees Celsius. Control group: This group is not subjected to any exercise intervention and supplement consumption. The percentage of people whose liver enzymes have decreased. Timepoint: Before and after interventions. Method of measurement: By measuring the liver enzymes in the blood in the laboratory. The percentage of people in whom the level of sirtuin 1 is increased. Timepoint: Before and after interventions. Method of measurement: Using ELISA method and Zelbio kit made in Germany. Vice President of Research at Danesh Alborz University Approved 2023-06-21 Ethics Committee of Sport Sciences Research Institute Fifth Alley, Mir Emad Ave., Ostad Motahari Ave Tehran Tehran Iran (Islamic Republic of)