]>
IRCT20221120056548N9 IRCT 2023-07-10 Vice President of Research at Danesh Alborz University The effect of exercise and consumption of grape seed extract on diabetes The effect of eight weeks of combined exercises and consumption of grape seed extract on some parameters of oxidative and antioxidant stress, total antioxidant capacity (tac), malondialdehyde (mda) and reduced glutathione (gsh) in women with diabetes 2023-07-12 anticipated 60 Complete https://irct.ir/trial/69778 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: In this randomization, the method of equal blocks (15 blocks of 4) has been used, in which a number of intervention people and a number of comparison people are included in each block, and we have allocated them to different groups. The method and tool of block random sequence generation has been done using https://www.sealedenvelope.com/simple-randomiser/v1/lists. N/A diabetes. Intervention 1: Intervention group: Sports intervention includes 8 weeks of combined exercises (selected aerobic and resistance exercises). According to the instructions of the American College of Sports Medicine (ACSM), the participants start training three times a week for fifty minutes, and the intensity and duration of the training is increased during 8 weeks. All exercises are performed under the supervision of a sports physiology specialist and in the health sports clinic. For aerobic exercise, participants choose to exercise on a treadmill or bicycle ergometer. Aerobic training sessions start from 20 minutes and with an intensity of 60% of the maximum heart rate in the first and second week and increase to 30 minutes and up to 70% of the maximum heart rate in the 8th week. During the training, the heart rate is monitored by a Polar T31 oy pacemaker. Resistance training begins with one set of 15 repetitions for each movement in the first two weeks, and finally the intensity of the training is increased to two or three sets of 10-120 repetitions. It increases in week 8. All resistance exercises are performed by means of gym machines and include chest press, leg press, cable underarm, cable front arm and cable back arm. The supplement group of grape seed extract is also consumed in the form of 200 mg capsules of grape seed extract of Vinicin Barrage essence for eight weeks and every day. Intervention 2: Control group: This group is not subject to any exercise intervention or supplement consumption. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 6 months after the results are published To whom: It will be available for researchers working in academic and scientific institutions. Conditions: If the intellectual rights are preserved, the data can be sent to the researchers. Where to obtain: Email address: saeidshamlou9092@gmail.com How to obtain: Submission of a written request (one week) Comments:
public Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University scientific Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University Iran (Islamic Republic of) Having diabetes being menopausal Age range 50-65 years 50 years 65 years Female History of cardiovascular disease Inability to exercise E08 Diabetes mellitus due to underlying condition Treatment - Other Treatment - Other Intervention group: Sports intervention includes 8 weeks of combined exercises (selected aerobic and resistance exercises). According to the instructions of the American College of Sports Medicine (ACSM), the participants start training three times a week for fifty minutes, and the intensity and duration of the training is increased during 8 weeks. All exercises are performed under the supervision of a sports physiology specialist and in the health sports clinic. For aerobic exercise, participants choose to exercise on a treadmill or bicycle ergometer. Aerobic training sessions start from 20 minutes and with an intensity of 60% of the maximum heart rate in the first and second week and increase to 30 minutes and up to 70% of the maximum heart rate in the 8th week. During the training, the heart rate is monitored by a Polar T31 oy pacemaker. Resistance training begins with one set of 15 repetitions for each movement in the first two weeks, and finally the intensity of the training is increased to two or three sets of 10-120 repetitions. It increases in week 8. All resistance exercises are performed by means of gym machines and include chest press, leg press, cable underarm, cable front arm and cable back arm. The supplement group of grape seed extract is also consumed in the form of 200 mg capsules of grape seed extract of Vinicin Barrage essence for eight weeks and every day. Control group: This group is not subject to any exercise intervention or supplement consumption. The percentage of people whose blood sugar levels have decreased. Timepoint: Before and after interventions. Method of measurement: By measuring blood sugar in the laboratory. The percentage of people in whom the level of total antioxidant capacity and reduced glutathione increased and malondialdehyde decreased. Timepoint: Before and after interventions. Method of measurement: Using ELISA method and Zell bio kit made in Germany. Vice President of Research at Danesh Alborz University Approved 2023-06-21 Ethics Committee of Sport Sciences Research Institute Fifth Alley, Mir Emad Ave., Ostad Motahari Ave Tehran Tehran Iran (Islamic Republic of)