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IRCT20221120056548N8 IRCT 2023-07-09 Vice President of Research at Danesh Alborz University Effect of exercise and consumption of garlic extract on diabetes The effect of eight weeks of resistance training and consumption of garlic Extract on some biomarkers of oxidative stress, malondialdehyde (MDA) and reduced glutathione (GSH) in women with hyperlipidemia and type 2 diabetes. 2023-07-12 anticipated 60 Complete https://irct.ir/trial/69785 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Education/Guidance, Randomization description: In this randomization, the method of equal blocks (15 blocks of 4) has been used, in which a number of intervention people and a number of comparison people are included in each block, and we have allocated them to different groups. The method and tool of block random sequence generation has been done using https://www.sealedenvelope.com/simple-randomiser/v1/lists. N/A diabetes. Intervention 1: Intervention group: Sports intervention includes 8 weeks of combined exercises (selected aerobic and resistance exercises). According to the instructions of the American College of Sports Medicine (ACSM), the participants start training three times a week for fifty minutes, and the intensity and duration of the training is increased during 8 weeks. All exercises are performed under the supervision of a sports physiology specialist and in the health sports clinic. During eight weeks of resistance training, in each training session, the subjects performed three lower body movements (leg press, front thigh press, and back thigh press) and six upper body movements (chest press, cable underarm, lateral push, cable back arm, front arm, and crunch). base) will be performed by starting the lower body movements and then the upper body with an intensity of 80% of a maximum repetition. These exercises will include three sets of 10 repetitions for both upper and lower body parts with 1 minute rest between sets and movements. The supplement group will be given a daily garlic capsule - each containing 500 mg of garlic extract supplement (produced by Goldaro, Iran) - for 8 weeks, and the third group will exercise and take the supplement at the same time. Intervention 2: Control group: This group is not subjected to any exercise intervention and supplement consumption. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 6 months after the results are published To whom: It will be available for researchers working in academic and scientific institutions. Conditions: If the intellectual rights are preserved, the data can be sent to the researchers. Where to obtain: Email address: saeidshamlou9092@gmail.com How to obtain: Submission of a written request (one week) Comments:
public Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University scientific Saeid Shamlou Kazemi
Mahdiyeh Ave
Hamadan Iran (Islamic Republic of) 6517838695 +98 81 3221 0929 saeidshamlou9092@gmail.com Bu-Ali Sina University Iran (Islamic Republic of) Having diabetes high blood fat being menopausal 50 years 65 years Female History of cardiovascular disease E08 Diabetes mellitus due to underlying condition Treatment - Other Treatment - Other Intervention group: Sports intervention includes 8 weeks of combined exercises (selected aerobic and resistance exercises). According to the instructions of the American College of Sports Medicine (ACSM), the participants start training three times a week for fifty minutes, and the intensity and duration of the training is increased during 8 weeks. All exercises are performed under the supervision of a sports physiology specialist and in the health sports clinic. During eight weeks of resistance training, in each training session, the subjects performed three lower body movements (leg press, front thigh press, and back thigh press) and six upper body movements (chest press, cable underarm, lateral push, cable back arm, front arm, and crunch). base) will be performed by starting the lower body movements and then the upper body with an intensity of 80% of a maximum repetition. These exercises will include three sets of 10 repetitions for both upper and lower body parts with 1 minute rest between sets and movements. The supplement group will be given a daily garlic capsule - each containing 500 mg of garlic extract supplement (produced by Goldaro, Iran) - for 8 weeks, and the third group will exercise and take the supplement at the same time. Control group: This group is not subjected to any exercise intervention and supplement consumption. The percentage of people whose blood sugar levels have decreased. Timepoint: Blood sugar measurement before and after the intervention. Method of measurement: By measuring blood sugar in the laboratory. The percentage of people whose blood fat level has decreased. Timepoint: Measurement of blood lipids before and after the intervention. Method of measurement: By measuring blood lipids in the laboratory. The percentage of people in whom the level of antioxidant glutathione increased and malondialdehyde decreased. Timepoint: Before and after interventions. Method of measurement: Using ELISA method and Zelbio kit made in Germany. Vice President of Research at Danesh Alborz University Approved 2023-06-21 Ethics Committee of Sport Sciences Research Institute Fifth Alley, Mir Emad Ave., Ostad Motahari Ave Tehran Tehran Iran (Islamic Republic of)