IRCT20121216011763N59 IRCT 2023-05-04 Esfahan University of Medical Sciences The effect of probiotic and vitamin D co-supplementation on migraine Evaluating the effect of probiotic and vitamin D co-supplementation on clinical indices, inflammation, oxidative stress, mental health, and quality of life in patients with migraine 2023-05-22 anticipated 70 Complete https://irct.ir/trial/69825 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Migraine patients will be randomly allocated to intervention and placebo groups in a 1:1 ratio using a four-block randomization method with stratification based on two variables of age (<40, ≥40 years) and sex (female, male). Block randomization will be done using a list of random numbers generated by the website https://www.sealedenvelope.com/simple and by an independent researcher. Investigators, data analysts, and neurologists will remain blinded to treatment allocation, Blinding description: This is a double-blind randomized controlled clinical trial. The required number of drugs and placebo (identical regarding color, smell, shape, and size) for each patient will be packaged in similar boxes by an independent researcher. 3 Migraine. Intervention 1: The patients in the intervention group will recieve for 12 weeks with a probiotic capsule per day (Farabiotic Company) and a vitamin D pearl (50000 IU) (Zahrava Company) every two weeks. Intervention 2: The patients in the control group will recieve for 12 weeks with a probiotic placebo capsule per day containing starch and maltodextrin and a vitamin D placebo pearl containing corn oil. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information