IRCT20121021011192N14 IRCT 2023-05-29 Shahid Beheshti University of Medical Sciences Efficacy and Safety of Sublingual Melatonin in alleviation of irratable Bowel Efficacy and Safety of Sublingual Melatonin in alleviation of IBS Symptoms 2023-06-22 anticipated 76 Complete https://irct.ir/trial/70077 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: 1:1 randomization, centralized web-based randomization and according to the entry and exit criteria, through random allocation by balanced block method, individuals are divided into two groups of control and experimental. Using Random Sequence Generator, groups are created and people are placed in one of these two groups based on the reference sequence, Blinding description: Participants, principle investigator, healthcare providers (Physicians, nurses) who care for participants during the trial, data collectors and outcome assessors all are blinded by providing placebo sublingual tablet in same size, shape color, odor and package with sublingual tablet of melatonin which organized just by one responsible co-researcher has no involvement in running study. 3 Irritable Bowel Syndrom. Intervention 1: Intervention group: Sublingual administration of 3 miligram of melatonin daily for 8 weeks. Intervention 2: Control group: Sublingual administration of melatonin placebo tablet daily for 8 weeks. Yes - There is a plan to make this available What will be shared: کل داده ها بالقوه پس از غیر قابل شناسایی کردن افراد قابل اشتراک گذاری است When: starting 6 months after publication To whom: for people working in academic institutions Conditions: general use Where to obtain: email to: m_abbasi@sbmu.ac.ir How to obtain: 10 working days after recieving request email Comments: