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IRCT20101130005280N62 IRCT 2023-06-13 Mashhad University of Medical Sciences Effectiveness of topical Nano-minoxidil and minoxidil on treatment of patients with androgenetic alopecia Determining and comparing the effectiveness of topical Nano-minoxidil and minoxidil on treatment of patients with androgenetic alopecia aged between 18-50 years 2023-06-15 anticipated 84 Complete https://irct.ir/trial/70151 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, permutation block method was used to generate a sequence of random allocation of individuals to the study groups. Random allocation sequence was performed using random allocation software and block size of four. The permutation block method is one of the random allocation methods in which each block is selected according to the number of groups studied, Blinding description: Participants and outcome assessors are fully aware of the subject of the subject, purpose, and procedure of the study. However, in order to prevent prediction of results and introduction of error into the study, they are unaware of the type of grouping and how patients are assigned to control and intervention groups. 2-3 Androgenetic alopecia. Intervention 1: Intervention group: In this group, patients are treated with 1 cc of 0.5% Nano-minoxidil (produced by Dr. Ali Moradi and Dr. Majid Daroudi in the nanobiotechnology department of the medical school of Mashhad university of Medical Sciences) locally on the scalp on a daily basis for 6 months. Intervention 2: Control group: In this group, patients are treated with 1 cc of 5% minoxidil locally on the scalp on a daily basis for 6 months. Yes - There is a plan to make this available What will be shared: All data can be shared after patients are made unidentifiable. When: Data can be accessible 6 months after results are published. To whom: Data can be accessible through an email to the corresponding author. Conditions: Data will be available for researchers in universities and other scientific institutes. Where to obtain: The data can be accessed through sending an email to Dr. Rozhan Farhadi via rozhanf45@gmail.com. How to obtain: After sending a request email to the researcher responsible for data collection, Dr. Rozhan Farhadi, at rozhanf45@gmail.com, the data will be provided within 1 month. Comments:
public Shatila Torabi
Imam Reza Hospital, next to Imam Reza square, Ibne Sina street
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 2406 TorabiSh@mums.ac.ir Mashhad University of Medical Sciences scientific Shatila Torabi
Imam Reza Hospital, next to Imam Reza square, Ibne Sina street
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 2406 TorabiSh@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients are between 18 and 50 years of age Patients with androgenetic alopecia (Sinclair stage 2-5) 18 years 50 years Both Hypertension Skin lesions such as psoriasis or blister on the scalp Severe Seborrhoeic dermatitis History of allergic reaction to minoxidil L64 Androgenic alopecia Treatment - Drugs Treatment - Drugs Intervention group: In this group, patients are treated with 1 cc of 0.5% Nano-minoxidil (produced by Dr. Ali Moradi and Dr. Majid Daroudi in the nanobiotechnology department of the medical school of Mashhad university of Medical Sciences) locally on the scalp on a daily basis for 6 months. Control group: In this group, patients are treated with 1 cc of 5% minoxidil locally on the scalp on a daily basis for 6 months. Hair density. Timepoint: Every 2 months for 6 months. Method of measurement: Trichoscopy. Hair diameter. Timepoint: Every 2 months for 6 months. Method of measurement: Trichoscopy. Mashhad University of Medical Sciences Approved 2022-11-14 Ethics Committee of Mashhad University of Medical Sciences Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah street Mashhad Razavi Khorasan Iran (Islamic Republic of)