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IRCT20220516054879N6 IRCT 2023-07-03 Rasht University of Medical Sciences The effects of Hypericum Perforatum and Dexpanthenol topical cream on the healing process of scar A comparative study of the effects of Hypericum Perforatum and Dexpanthenol topical cream on the healing process of scar caused by neck surgeries 2023-06-03 anticipated 48 Complete https://irct.ir/trial/70216 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The 4 permutation block randomization method was used to randomize patients into two groups. Given that Group A is the intervention group and Group B is the control group. Randomization was done with SAS software version 9. For allocation concealment, opaque-sealed envelopes will be used, Blinding description: This is a double-blind study. Comparison of color and smell between Hypericum and Dexpanthenol creams will be done using allowed color and essential oil. The type of treatment will be placed inside a sealed envelope and delivered to the nurse and statistical analyst. The researcher and the participant will be blind. 3 Scar caused by neck surgery. Intervention 1: Intervention group: Receiving 3 times a day topical cream formulation of Hypericum perforatum plant with 70% ethanolic extract with 2% concentration of total extract for 3 months. Intervention 2: Control group: Receiving 3 times a day Dexpanthenol 5% topical cream from Raha Pharmaceutical Company for 3 months. No - There is not a plan to make this available Justification or reason for not sharing IPD is Patient privacy and ethical principles
public Maryam Shahrokhi
17shahrivar Hospital, Shahid Siadati Street, Namjoo Street
Rasht Iran (Islamic Republic of) 414465379 +98 13 3336 9019 shahrokhi.mail85@gmail.com Rasht University of Medical Sciences scientific Maryam Shahrokhi
17shahrivar Hospital, Shahid Siadati Street, Namjoo Street
Rasht Iran (Islamic Republic of) 4144654379 +98 13 3336 9019 shahrokhi.mail85@gmail.com Rasht University of Medical Sciences Iran (Islamic Republic of) Patients with neck wounds caused by surgery After removing the stitches obtaining informed consent 18 years no limit Both Previous sensitivity to products containing Hypericum Perforatom Receiving other drugs effective on wound healing Suffering from diseases that interfere with wound healing (chronic systemic diseases of the heart, kidney, lung, coagulation disorder, immune deficiency, connective tissue disorder, diabetes, anemia, hemophilia, and malnutrition) Having a history of previous injury or surgery and visible lesions in the neck area L90.5 Scar conditions and fibrosis of skin Treatment - Drugs Placebo Intervention group: Receiving 3 times a day topical cream formulation of Hypericum perforatum plant with 70% ethanolic extract with 2% concentration of total extract for 3 months. Control group: Receiving 3 times a day Dexpanthenol 5% topical cream from Raha Pharmaceutical Company for 3 months Scar spread. Timepoint: Scar spread will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Erythema. Timepoint: Erythema will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Dyspigmentation. Timepoint: Dyspigmentation will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Track marks or suture marks. Timepoint: Track marks or suture marks will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Hypertrophy/atrophy. Timepoint: Hypertrophy/atrophy will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Overall impression. Timepoint: Overall impression will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on the observation of the researcher. Pain. Timepoint: Pain will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on questions from the patient. Itch. Timepoint: Itch will be measured at the beginning of the study and then weekly for 3 months. Method of measurement: Based on questions from the patient. Rasht University of Medical Sciences Approved 2023-05-03 Ethics committee of Guilan University of Medical Sciences Deputy of research and technology, In front of 17 shahrivar hospital, Shaid siadati street,Namjoo street, Rasht Rasht Guilan Iran (Islamic Republic of)