IRCT20230526058293N1 IRCT 2023-05-31 Islamic Azad University Comparison of the effect of local marcaine (port location) with intraperitoneal marcaine on painafter laparoscopic cholecystectomy Comparison of the effect of local marcaine (port location) with intraperitoneal marcaine on painafter laparoscopic cholecystectomy 2023-06-22 anticipated 28 Complete https://irct.ir/trial/70366 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be randomly divided into two groups with the help of sealed envelopes Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm, Blinding description: This study will be conducted in the form of a two-group, single-blind clinical trial, where the patients will be unaware of the assigned treatment, on patients undergoing elective laparoscopic cephalocystectomy surgery at Aria Hospital in Mashhad. People with entry criteria and those without exit criteria will enter the study after providing an explanation about the design and completing the informed consent form. Patients will be randomly divided into two groups with the help of sealed envelopes Group 1: Local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the procedure before closing the wound, which will be 5 ml per port. Group 2: After removing the gallbladder, they will receive intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm. 2-3 Comparison of the effect of local marcaine (port location) with intraperitoneal marcaine on painafter laparoscopic cholecystectomy. Intervention 1: Intervention group Group 2: After removal of the gallbladder, intraperitoneal infiltration of 20 ml of 0.25% bupivacaine solution in the bed of the gallbladder and under the right dome of the diaphragm. Intervention 2: Control group: Intervention group: Group 1: local infiltration (port site) of 20 ml of 0.25% bupivacaine solution at the end of the operation before closing the wound. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information