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IRCT20230513058161N2 IRCT 2023-08-11 Shiraz University of Medical Sciences Effect of Stimulation along with Affective Expectations Manipulation on Anhedonia Effect of Transcranial Direct Current Stimulation along with Affective Expectations Manipulation on Affective Experience and Anhedonia among Anhedonic Patients Suffering from Major Depression Disorder 2023-06-22 anticipated 45 Complete https://irct.ir/trial/70376 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Allocation of people to desired groups by simple random method and by lottery. For this purpose, we prepare three sheets on which we write the experimental groups. Then, with each patient's visit, one of the sheets is randomly removed and the patient is assigned to the selected group, Blinding description: All the participants will be explained how the device works, and all individuals who participate in the study think that they will receive the intervention, however, some do not. In this way, after placing the transcranial direct current stimulation device on the subjects' heads, some receive actual stimulation, while others receive fake or sham stimulation. N/A Major Depression Disorder. Intervention 1: Intervention group 1: transcranial direct current stimulation and then induction of positive emotions. In this group, the participants first receive electrical stimulation through one session, at the rate of 2 milliamps for 20 minutes, on the dorsomedial prefrontal cortex via the tDCS device, and then positive emotions will be induced. In this way, the short pleasurable video clip will be shown to the subject at the end of the stimulation. Before playing the movie, the positive emotional information about the movie will be presented to the subjects in order to manipulate the emotional expectations of the individuals. Intervention 2: Intervention group 2: Sham transcranial electrical stimulation then induction of positive emotions. In this group, during a session the participants first receive sham stimulation on the dorsomedial prefrontal cortex through the tDCS device, and then positive emotions are induced. In this way, at the end of the stimulation, the person will be shown the desired short pleasurable movie, and before playing the movie, in order to manipulate the emotional expectations of the person, positive emotional information about the movie will be presented to the person. Intervention 3: Intervention group 3: In this group, during a session the participants first receive electrical stimulation at the rate of 2 milliamps for 20 minutes on the dorsomedial prefrontal cortex through the tDCS device, and then neutral emotions are induced. In this way, at the end of the stimulation, the person will be shown the desired short pleasurable movie, and before playing the movie, neutral emotional information about the movie will be presented to the person. Yes - There is a plan to make this available What will be shared: All data can be shared in spss file format When: One month after results publication To whom: Researchers working in academic and scientific institutions Conditions: The data can be used for any statistical analysis, subject to permission from the researchers Where to obtain: E-mail address of the corresponding author How to obtain: After request, the responsible author will send the data within a maximum period of one month. Comments:
public Somayeh Daneshvar
Hafez Hospital, Chamran Blv
Shiraz Iran (Islamic Republic of) 71946-34786 +98 71 3647 9080 somayedaneshvar@sums.ac.ir Shiraz University of Medical Sciences scientific Somayeh Daneshvar
Hafez Hospital, Chamran Blv
Shiraz Iran (Islamic Republic of) 7194634786 +98 71 3647 9080 somayedaneshvar@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Obtaining the initial diagnosis of major depressive disorder with anhedonia using a structured clinical interview and questionnaire. The patient should be able to perform the behavioral test and answer the questionnaires. 18 years 65 years Both The presence of comorbid disorders such as substance abuse, psychotic disorders, bipolar disorder, anxiety disorders, and psychotic symptoms. The presence of metal parts in the head F32.2 Severe depressive episode without psychotic symptoms Treatment - Other Treatment - Other Treatment - Other Intervention group 1: transcranial direct current stimulation and then induction of positive emotions. In this group, the participants first receive electrical stimulation through one session, at the rate of 2 milliamps for 20 minutes, on the dorsomedial prefrontal cortex via the tDCS device, and then positive emotions will be induced. In this way, the short pleasurable video clip will be shown to the subject at the end of the stimulation. Before playing the movie, the positive emotional information about the movie will be presented to the subjects in order to manipulate the emotional expectations of the individuals. Intervention group 2: Sham transcranial electrical stimulation then induction of positive emotions. In this group, during a session the participants first receive sham stimulation on the dorsomedial prefrontal cortex through the tDCS device, and then positive emotions are induced. In this way, at the end of the stimulation, the person will be shown the desired short pleasurable movie, and before playing the movie, in order to manipulate the emotional expectations of the person, positive emotional information about the movie will be presented to the person. Intervention group 3: In this group, during a session the participants first receive electrical stimulation at the rate of 2 milliamps for 20 minutes on the dorsomedial prefrontal cortex through the tDCS device, and then neutral emotions are induced. In this way, at the end of the stimulation, the person will be shown the desired short pleasurable movie, and before playing the movie, neutral emotional information about the movie will be presented to the person. Anhedonia. Timepoint: Before and after the intervention. Method of measurement: Positive Valence Systems Scale-21 questionnaire. Probabilistic reward. Timepoint: Before and after the intervention. Method of measurement: Probabilistic reward task. Shiraz University of Medical Sciences Approved 2023-05-28 Ethics Committee of Shiraz University of Medical Sciences 5th floor, Shiraz University Central Building, Islamic Republic Blv, Shiraz Shiraz Fars Iran (Islamic Republic of)