IRCT20221026056313N1 IRCT 2023-07-24 Shahid Beheshti University of Medical Sciences Efficacy and safety of primary Needle Knife Fistulotomy in patients undergoing ERCP with a long papilla Efficacy and safety of primary Needle Knife Fistulotomy in patients undergoing ERCP with a long papilla: A single blind randomized prospective study 2023-08-06 anticipated 181 Complete https://irct.ir/trial/70551 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are assigned to two groups using the random block method. The number of blocks will be 4 and in each block three patients will be included in the study order. Random allocation of blocks of patients to two treatment groups will be done through Sealed Envelope online software. The randomized list of blocks is placed in sealed envelopes and will be provided to the endoscopist on a daily basis, Blinding description: The study will be done in a blind way. The evaluator does not know how to assign patients to the group in order to prevent misuse in measuring the results of the study. N/A bile duct disorder. Intervention 1: Intervention group: Intervention group: In the first group, the bile ducts of the patients will be cannulated with a standard technique. In this technique, the guidewire enters the bile duct through the papilla. Patients will undergo ERCP in one session, and its duration will be between 20 and 60 minutes, depending on the difficulty of cannulation. Intervention 2: Intervention group: In the second group, entry into the bile duct will be done with the basic needle-knife technique. In this technique, first an incision is made above the papilla hole, and then the guidewire will enter the bile duct through this incision. Patients will undergo ERCP in one session, and its duration will be between 20 and 60 minutes depending on the difficulty of cannulation. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information