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IRCT20110531006660N5 IRCT 2018-01-12 Mazandaran University of Medical Sciences Effect of Omega3 in Treatment of Chronic Urticaria Evaluation of Omega3 Function in the Treatment of Chronic Urticarial, with Clinical Evaluation and Adaptive Innate Immune Response in the double-blind Model 2017-12-22 anticipated 60 Complete https://irct.ir/trial/7086 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this Study, Simple Randomization Method is Used with the Numerical Table, Blinding description: In this Study, Research Fellow, Specialist Evaluating the Clinical Conditions and the Delivery of the Drug is not Aware of how the Drug is Administered, and the Drugs will be Delivered to the Patient in the Numbered Package to the Patient and the Packet Number will be Recorded in the list of Patients. As well as those who Receive the drug, are not Aware of the Placebo, and are being Evaluated. 2 Chronic urticaria. Intervention 1: First Intervention group: Omega3 Containing 180 mg of EPA and 120 mg of DHA, one Daily for 3 Months. Intervention 2: Intervention group: This Group will Receive the Placebo-Omega-3 drug. Intervention 3: Control group: Omega-3 Placebo, one Daily for 3 Months. Yes - There is a plan to make this available What will be shared: In this Study, all the Information on the main Outcome that Includes the Patient's clinical Recovery, as well as the Side Effects Including the Evaluation of serum proteins, Including cytokines, are Shared after taking the Drug When: The time to Start Accessing Data will be one Month after the Data is Printed To whom: The Data in this Study is Available to Researchers in Academic and Scientific Institutions as well as in Non-Related Fields. Conditions: The Data is Available after Printing and the Specified time Period and is used to Improve the Scientific Level Where to obtain: Dr.Javad Ghaffari Email: Ghafari@mazumse.ac.ir Contact Number: 09113510359 How to obtain: This Data will be Available to the Applicant one Month after Printing Comments:
public Dr.Javad Ghaffari
Research and Technology Dept, Building No. 2, Teacher's Square, Teacher's Street
Sari Iran (Islamic Republic of) 48157-33971 +1 133257230 ghafari@mazums.ac.ir Mazandaran University of Medical Sciences scientific Dr.Javad Ghaffari. Dr Alireza Rafiei
Research and Technology Dept, Building No. 2, Teacher's Square, Teacher's Street
Sari Iran (Islamic Republic of) 48157-33971 +1 133257230 ghafari@mazums.ac.ir Mazandaran University of Medical Sciences Iran (Islamic Republic of) Chronic Idiopathic Urticaria Age between 10 and 40 Years Old Receiving Antihistamines Patient Approval Completion of Treatment for at least 30 Days 10 years 40 years Both Concomitant illness; whether allergic or non-allergic ; Use of non-Antihistamine Medication Age Less than 10 and above 40 Acute Hives Physical Urticaria Hypersensitivity or Antihistamine Anaphylaxis Pregnant Women L50.1 Idiopathic urticaria Treatment - Drugs Placebo Treatment - Drugs First Intervention group: Omega3 Containing 180 mg of EPA and 120 mg of DHA, one Daily for 3 Months. Intervention group: This Group will Receive the Placebo-Omega-3 drug Control group: Omega-3 Placebo, one Daily for 3 Months. Clinical resolution of urticaria. Timepoint: before and after treatment. Method of measurement: UAS7. Thymic Stromal Lymphopoietin (TSLP). Timepoint: Before intervention and 3 months after intervention. Method of measurement: Reverse Transcription Polymerase Chain Reaction (RT-PCR) and Enzyme-Linked Immunosorbent Assay (ELIZA). Interferon Gama. Timepoint: Before intervention and 3 months after intervention. Method of measurement: RT-PCR و ELIZA. Interleukine4 (IL4). Timepoint: Before intervention and 3 months after intervention. Method of measurement: RT-PCR و ELIZA. IL35. Timepoint: Before intervention and 3 months after intervention. Method of measurement: RT-PCR و ELIZA. IL32. Timepoint: Before intervention and 3 months after intervention. Method of measurement: RT-PCR و ELIZA. Mazandaran University of Medical Sciences Approved 2017-07-31 Mazandaran University of Medical Sciences Sari, Khazar Square, Farah Abad Road, Km 18, Complex of the Great Prophet Sari Mazandaran Iran (Islamic Republic of)