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IRCT20220317054318N4 IRCT 2023-07-05 Hamedan University of Medical Sciences The effect of prp on oligospermia PRP Evaluate the effect of platelet-rich plasma(PRP) by testicular injection on sperm DNA fragmentation index of infertile men with sever oligoasthenoteratozoospermia (OAT) 2023-07-23 anticipated 160 Complete https://irct.ir/trial/70869 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: Randomization is done by block method. We prepare 18 sheets of paper and write A on 9 sheets and B on other 9 sheets and put them in the drawer of the table and then each person with Inclusion criteria , one of the sheets will be given to the person randomly. Allocated and assigned to the intervention and control groups based on the letter A or B, Blinding description: People participating in the study are unaware of the assigned group. N/A Oligostenoteratozoospermia. Intervention 1: Intervention group: Includes sample subjects receiving platelet-rich plasma via intratesticular injection. Intervention 2: Control group: Sample subjects receiving routine treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Shamim pilehvari
Pasdaran Street
Hamedan Iran (Islamic Republic of) ۶۵۱۷۸۳۸۶۷۸ +98 81 3131 4058 Sh.pilehvari@yahoo.com Hamedan University of Medical Sciences scientific Shamim pilehvari
Pasdaran Street
Hamedan Iran (Islamic Republic of) ۶۵۱۷۸۳۸۶۷۸ +98 81 3131 4058 sh.pilehvari@yahoo.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Age range 20-45 years Sperm count <20 million Movement less than 106 x 5 ml, progressive movement < 20%, normal morphology < 10% Not receiving other treatments such as hormone therapy Not suffering from underlying diseases (such as diabetes, kidney disease, liver disease, drug and alcohol addiction) and types of cancer and receiving chemotherapy treatments Absence of signs of infection in semen Untreated varicocele 25 years 45 years Male Unwillingness to continue participating in the study N46.1 Oligospermia Treatment - Other Treatment - Drugs Intervention group: Includes sample subjects receiving platelet-rich plasma via intratesticular injection Control group: Sample subjects receiving routine treatment Sperm DNA fragmentation index. Timepoint: Before the start of the intervention and after 3 months from the time of PRP injection. Method of measurement: Sperm DNA breakage index test. Hamedan University of Medical Sciences Approved 2023-06-10 Ethics committee of Hamedan University of Medical Sciences Fatemieh Hospital, Pasdaran St. Hamedan Hamadan Iran (Islamic Republic of)