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IRCT20230710058733N1 IRCT 2023-09-26 Islamic Azad University Comparison of pain after abdominal surgery in patients receiving ketorolac and nasocalcin spray or lidocaine and nasocalcin spray Comparison of pain after abdominal surgery in patients receiving ketorolac and nasocalcin spray or lidocaine and nasocalcin spray 2021-09-20 anticipated 59 Complete https://irct.ir/trial/71195 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: In this study, a list of all patients who were willing to participate in the study was first prepared, and after matching the patients who met the inclusion criteria, we assigned a number to each patient. We considered numbers 1 to 29 as group A and 30 to 59 as group B. So, using the online random number table, the patients were divided into two groups (A group receiving intravenous nasocalcin spray and Ketorolac ampoule and B group receiving intravenous nasocalcin spray and lidocaine ampoule), Blinding description: This research is a double-blind clinical trial (in order to make this study double-blind, the drugs used for the patients at the beginning of the study are A/B by the supervisor of the surgery department so that the clinical caregiver and the participants do not know the type of drug received. 2 Pain after abdominal surgery. Intervention 1: 2 puffs of nasocalcin and Ketorolac 30 mg ampoules were received intravenously. After patients enter the operating room, patients under general anesthesia with the same drugs (propofol 2 mg per kg of patient weight or Nesdonal 5 mg per kg of patient weight, midazolam 0.01 mg per kg of patient weight, fentanyl 2 - 3 macros per kilogram of patient weight and atrocurium 0.5 mg per kilogram of patient weight for induction and for maintenance, 1-2% isoflurane and oxygen N2o (50/50) were used. For patients during surgery, 1 macro per Every kilogram of the patient's weight, fentanyl was repeated every hour, and then at the end of the surgery, the reverse muscle relaxant was performed by a mixture of neostigmine and atropine. Then, after the surgery and at 6, 12, 24 hours after the operation, the pain level of the patients was measured according to the pattern VAS was checked and in case of VAS>5, pethidine 30-50mg was injected intravenously to the patients and at the end of the first day, the amount of narcotic used was recorded in the questionnaire by a trained nurse. Intervention 2: They received 2 puffs of nasocalcin spray and lidocaine ampoules intravenously, and after the patients entered the operating room, the patients were under general anesthesia with the same drugs (propofol 2 mg per kg of patient weight or Nesdonal 5 mg per kg of patient weight) , midazolam 0.01 mg per kg of patient weight, fentanyl 2-3 macros per kg of patient weight and atrocurium 0.5 mg per kg of patient weight for induction and for maintenance of isoflurane 1-2% and oxygen N2o (50/50) ) was used. For patients during surgery, 1 macro per kilogram of the patient's weight of fentanyl was repeated every hour, and then at the end of the surgery, a reverse muscle relaxant was performed by a mixture of neostigmine and atropine. Then after the surgery and at 6 hours , 12,24, after the operation, the pain level of the patients was checked based on the VAS model, and in the case of VAS>5, pethidine 30-50 mg was injected intravenously to the patients, and at the end of the first day, the amount of narcotic used was recorded in a questionnaire by a trained nurse. It was registered. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Dr. Mahnaz Narimani Zamanabadi
At the beginning of Damāvand Street, Imam Hossein Square, Tehran
Tehran Iran (Islamic Republic of) 1676855733 +98 21 7719 0836 Mahdieh.ir72@yahoo.com Islamic Azad University scientific Mahnaz Narimani Zamanabadi
At the beginning of Damāvand Street, Imam Hossein Square, Tehran
Tehran Iran (Islamic Republic of) 1676855733 +98 21 7719 0836 mahdieh.ir72@yahoo.com Islamic Azad University Iran (Islamic Republic of) Being 15-75 years old Sign a personal consent form to enter the study American Society of Anesthesiologists 1-2 Non-use of drugs and alcohol Elective surgery 15 years 75 years Both Decreased level of consciousness Hemodynamic disorder Abnormal intraoperative bleeding Length of operation more than 4 hours T81.9 Unspecified complication of procedure Prevention Prevention 2 puffs of nasocalcin and Ketorolac 30 mg ampoules were received intravenously. After patients enter the operating room, patients under general anesthesia with the same drugs (propofol 2 mg per kg of patient weight or Nesdonal 5 mg per kg of patient weight, midazolam 0.01 mg per kg of patient weight, fentanyl 2 - 3 macros per kilogram of patient weight and atrocurium 0.5 mg per kilogram of patient weight for induction and for maintenance, 1-2% isoflurane and oxygen N2o (50/50) were used. For patients during surgery, 1 macro per Every kilogram of the patient's weight, fentanyl was repeated every hour, and then at the end of the surgery, the reverse muscle relaxant was performed by a mixture of neostigmine and atropine. Then, after the surgery and at 6, 12, 24 hours after the operation, the pain level of the patients was measured according to the pattern VAS was checked and in case of VAS>5, pethidine 30-50mg was injected intravenously to the patients and at the end of the first day, the amount of narcotic used was recorded in the questionnaire by a trained nurse. They received 2 puffs of nasocalcin spray and lidocaine ampoules intravenously, and after the patients entered the operating room, the patients were under general anesthesia with the same drugs (propofol 2 mg per kg of patient weight or Nesdonal 5 mg per kg of patient weight) , midazolam 0.01 mg per kg of patient weight, fentanyl 2-3 macros per kg of patient weight and atrocurium 0.5 mg per kg of patient weight for induction and for maintenance of isoflurane 1-2% and oxygen N2o (50/50) ) was used. For patients during surgery, 1 macro per kilogram of the patient's weight of fentanyl was repeated every hour, and then at the end of the surgery, a reverse muscle relaxant was performed by a mixture of neostigmine and atropine. Then after the surgery and at 6 hours , 12,24, after the operation, the pain level of the patients was checked based on the VAS model, and in the case of VAS>5, pethidine 30-50 mg was injected intravenously to the patients, and at the end of the first day, the amount of narcotic used was recorded in a questionnaire by a trained nurse. It was registered. Pain. Timepoint: 1 hour and 6, 12, 24 hours after the operation, the amount. Method of measurement: Visual Analogue Scale. The amount of narcotic (pethidine) received after the operation. Timepoint: After surgery. Method of measurement: Amount of drug used. Islamic Azad University Approved 2022-08-15 Ethics Committee of Tehran Islamic Azad University of Medical Sciences Head Office of Islamic Azad University of Medical Sciences, Tehran, Ayene Boulevard, Nabsheh Giley Street, Amir Pabarja Street, Do Rahi Kolak, Dr. Shariati Street, Tehran Tehran Tehran Iran (Islamic Republic of)