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IRCT20120912010824N3 IRCT 2023-09-07 Kermanshah University of Medical Sciences Resistance Training and Multiple Sclerosis Effects of 12 weeks of Resistance Exercise Training on Serum Indices in Permeability of Blood Brain Barrier Controlling, oxidative stress, Functional capacity and cognitive performance in Women with Multiple Sclerosis 2021-05-07 anticipated 30 Complete https://irct.ir/trial/71215 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Other, Randomization description: 30 eligible women with relapsing-remitting MS were selected to enter the study based on inclusion/exclusion criteria. Finally, the participants were divided into two groups a) without resistance training (15 people) and b) resistance training (15 people) by simple random method and using a table of random numbers. In addition, fifteen healthy, non-athlete women aged 18-45 were selected as a healthy control group (n = 15) to monitor the current research data. 3 Multiple Sclerosis. Intervention 1: Intervention group: Resistance Training, Based on the recommendations in Resistance training (RT) for pwMS, the RT program included 12 weeks, 3 sessions/week, 60-80% 1RM for 60–90 min/session. The RT program consisted of three exercises for the lower extremity (leg press, lunges, and deadlift), three exercises for the upper extremity (bench press, wide grip lat pulldown and front dumbbell raise).The training program started with a 5-minute warm-up on the ergometer bike, followed by the main exercises, and then the training program ended in each session with a 5-minute cool-down program on the ergometer bike and 5 minutes of stretching and relaxation. Also, during this period, Patients received their drug treatment supervised by specialist neurologist. Intervention 2: Control group: Women with MS without resistance training, These women did not participate in any exercise training during the 12 weeks of intervention and performed their normal daily activities. Also, during this period, they received their drug treatment supervised by specialist neurologist. Intervention 3: Control group2: Healthy women without resistance training, in the same age group (18-45) were selected as a healthy control group to monitor the research data.These women did not participate in any exercise training during the 12 weeks of intervention and performed their normal daily activities. Yes - There is a plan to make this available What will be shared: No known time When: No known time To whom: Scientific Conditions: Research using Where to obtain: نویسنده مسول How to obtain: Email Comments: No
public Nasrin Niazi Nezhad
Razi University
Kermanshah Iran (Islamic Republic of) 6714414874 0834283276 n.niazi64@gmail.com Kermanshah University of Medical Sciences scientific Abdolhossein Parnow
Razi university
Kermanshah Iran (Islamic Republic of) 6714414874 +98 83 3428 3276 parnowabdolhossein@gmail.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) history of at least two-year diagnosed RR-MS EDSS ≤4 no other chronic diseases (metabolic, cardiovascular, renal, …) no history of regular physical activity in the previous 6 months 18 years 45 years Female No contracting COVID-19 F06.8 Other specified mental disorders due to known physiological condition Rehabilitation Other Other Intervention group: Resistance Training, Based on the recommendations in Resistance training (RT) for pwMS, the RT program included 12 weeks, 3 sessions/week, 60-80% 1RM for 60–90 min/session. The RT program consisted of three exercises for the lower extremity (leg press, lunges, and deadlift), three exercises for the upper extremity (bench press, wide grip lat pulldown and front dumbbell raise).The training program started with a 5-minute warm-up on the ergometer bike, followed by the main exercises, and then the training program ended in each session with a 5-minute cool-down program on the ergometer bike and 5 minutes of stretching and relaxation. Also, during this period, Patients received their drug treatment supervised by specialist neurologist. Control group: Women with MS without resistance training, These women did not participate in any exercise training during the 12 weeks of intervention and performed their normal daily activities. Also, during this period, they received their drug treatment supervised by specialist neurologist. Control group2: Healthy women without resistance training, in the same age group (18-45) were selected as a healthy control group to monitor the research data.These women did not participate in any exercise training during the 12 weeks of intervention and performed their normal daily activities. Indices Related to Blood Brain Barrier Permeability (matrix metalloproteinases (MMPs) and specific tissue inhibitors of MMPs, s100B). Timepoint: pre and post of exercise protocol. Method of measurement: blood sampling. Cognitive Performance. Timepoint: pre and post of exercise protocol. Method of measurement: The Brief International Cognitive Assessment for MS (BICAMS) was used to examine information processing speed and immediate verbal and visual recall. The BICAMS consists of the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT-II) and the Brief Visuospatial Memory Test- Revised (BVMT-R). Personal Approved 2022-06-24 Research Working Group at the Sports Sciences Research Institute Motahari Street Tehran Tehran Iran (Islamic Republic of)