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IRCT20230725058916N1 IRCT 2023-08-01 Shahid Beheshti University of Medical Sciences Examining the benefits of combination treatment in acne Investigating the efficacy of Subcision with and without carboxytherapy in the treatment of atrophic acne scars 2023-09-06 anticipated 25 Complete https://irct.ir/trial/71598 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation software is used to allocate the treatment groups into two groups of Subcision alone and Subcision and carboxytherapy. N/A Atrophic acne scars. Intervention 1: Intervention group: Patients receive both Subcision and carboxytherapy on one side of the face. First, a tumescent solution is injected into the acne scar area. Fibrotic tissues are slowly separated by the blunt blade cannula. Finally, the cannula entry area is bandaged. Three sessions of carboxytherapy are performed with a pressure of 275-320, and a volume of 50-70 cc of gas is injected using an insulin needle. Intervention 2: Control group: Patients only receive Subcision on the other side of the face. Yes - There is a plan to make this available What will be shared: The anonymous dataset is available for sharing with researchers upon a reasonable request. The study protocol, analysis, and results will be published in the form of research articles. When: The dataset is accessible 6 months after the results are published To whom: All researchers upon a reasonable request Conditions: Systematic review and meta-analysis, for the researcher's own knowledge Where to obtain: Corresponding author's email or the information mentioned for the person corresponding to update the state of the clinical trial How to obtain: After receiving the request, a decision is made after consulting with the research members and the decision to provide the data file to the researcher is announced to her/him. Comments:
public Mahdi Gheysari
Loghman-e-Hakim Hospital, Makhsoos St., Tehran, Iran
Tehran Iran (Islamic Republic of) 1333635445 +98 21 5102 5000 Dr.mehdigheisari@gmail.com Shahid Beheshti University of Medical Sciences scientific Mahdi Gheysari
Loghman-e-Hakim Hospital, Makhsoos St., Tehran, Iran
Tehran Iran (Islamic Republic of) 1333635445 +98 21 5102 5000 Dr.mehdigheisari@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Adult patients with atrophic rolling acne scars 18 years no limit Both Active acne Active bacterial or viral infections Bleeding disorders Current use of systemic retinoids or during the last year Hypertrophic scars Hypersensitivity to anesthesia drugs L70.0 Acne vulgaris Treatment - Other Treatment - Other Intervention group: Patients receive both Subcision and carboxytherapy on one side of the face. First, a tumescent solution is injected into the acne scar area. Fibrotic tissues are slowly separated by the blunt blade cannula. Finally, the cannula entry area is bandaged. Three sessions of carboxytherapy are performed with a pressure of 275-320, and a volume of 50-70 cc of gas is injected using an insulin needle. Control group: Patients only receive Subcision on the other side of the face Atrophic scar improvement. Timepoint: One and three months after treatment. Method of measurement: Comparison of photos before and after treatment, comments of the patient and the attending physicians (2 physicians) (Goodman and Baron's acne scar grading system). Shahid Beheshti University of Medical Sciences Approved 2023-03-12 Research Ethics Committee of Skin Research Center-Shahid Beheshti University of Medical Sciences Skin Research Center, Mino Dead end Alley, Shahrdari St., Tehran, Iran Tehran Tehran Iran (Islamic Republic of)