IRCT20130418013058N17 IRCT 2023-08-02 Mashhad University of Medical Sciences Investigating the effect of crocin in multiple sclerosis patients Investigating the effect of crocin on the severity of fatigue, pain and quality of life in patients with multiple sclerosis 2023-10-12 anticipated 40 Complete https://irct.ir/trial/71629 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For each tablet container, four-digit codes will be Randomly labeled to Each Box by pharmacist . The Therapist will give it to the Patient Randomly without Knowledge of the Type of Medicine. Thus, the nature of each code will not be known until the analysis of the results, Blinding description: Crocin and placebo tablets will be prepared in a similar shape, color, and size, stored in a dark container and coded by a pharmacist. The physician, researcher and patients will not be aware of the code printed on the container. 2-3 MS or multiple sclerosis. Intervention 1: Intervention group: who receive one 15 mg crocin tablet daily for two months. Intervention 2: Control group: Placebo recipients (placebo), who receive one placebo tablets daily for two months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After the project, the information will be published in the form of an article.