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IRCT20230802059009N1 IRCT 2023-10-26 Mazandaran University of Medical Sciences Comparison of the effect of injectable and topical dexamethasone on dental surgery complications Comparison of the Clinical Effect of Injectable and Topical Dexamethasone on Complications After Mandibular Third Molar Surgery- A Clinical Study 2022-08-23 anticipated 30 Complete https://irct.ir/trial/71802 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study, random block method will be used to assign samples to groups. Blocks will be considered as 3 blocks. Group type selection for each person will be done through the following site. www.sealedenvelope.com/simple-randomiser/v1/lists, Blinding description: The study is double-blinded, and the surgeon and the researcher will not know about the patient groups. Only one person (student) who administers anesthetic and corticosteroid injection will be aware of the group of patients. The surgeon and the person who follows up the patients and records their pain and swelling levels will not know about the patient group. N/A impacted third molars. Intervention 1: Control group: This group only receives painkillers (400 mg ibuprofen) after surgery. Patients are advised to use this painkiller every 8 hours if they feel any pain. Intervention 2: Intervention group 1: In this group, after surgery, 2 ml of dexamethasone 8 mg (Daro Pasha, Tehran, Iran) will be injected into the medial pterygoid muscle with a 24-gauge syringe, and ibuprofen 400 mg will be prescribed. Intervention 3: Intervention group 2: In this group, after the surgery, 10 mg of dexamethasone sodium phosphate powder (Daro Pasha, Tehran, Iran) will be gradually placed in the socket of the extracted tooth, and 400 mg ibuprofen pain reliever will also be prescribed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no further data exists
public Soheil Soltani
Moallem avenue
Sari Iran (Islamic Republic of) ۳۳۹۷۱-۴۸۱۵۷ +98 11 3304 4000 soheil.soltani2016@yahoo.com Mazandaran University of Medical Sciences scientific Dr. Amirhossein Moaddabi
Moallem avenue
Sari Iran (Islamic Republic of) ۳۳۹۷۱-۴۸۱۵۷ +98 11 3304 4000 a.moaddabi2@gmail.com Mazandaran University of Medical Sciences Iran (Islamic Republic of) age of 17 to 35 personal informed consent having mesioangular impacted 3rd molar in the mandible not having a history of antibiotic consumption over the last 3 weeks 17 years 35 years Both systemic diseases such as diabetes or blood pressure Being allergic to dexamethasone Having pericoronitis or infection pregnancy drug consumption K01.1 Impacted teeth Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: This group only receives painkillers (400 mg ibuprofen) after surgery. Patients are advised to use this painkiller every 8 hours if they feel any pain Intervention group 1: In this group, after surgery, 2 ml of dexamethasone 8 mg (Daro Pasha, Tehran, Iran) will be injected into the medial pterygoid muscle with a 24-gauge syringe, and ibuprofen 400 mg will be prescribed. Intervention group 2: In this group, after the surgery, 10 mg of dexamethasone sodium phosphate powder (Daro Pasha, Tehran, Iran) will be gradually placed in the socket of the extracted tooth, and 400 mg ibuprofen pain reliever will also be prescribed. Swelling. Timepoint: before surgery, 2 days, and 7 days after surgery. Method of measurement: The amount of swelling will be measured clinically, from the tragus of the ear to the outer corner of the mouth on the surgical side by a tape adjusted to the natural concavity of the patient's face. Trismus. Timepoint: before surgery, 2 days, and 7 days after surgery. Method of measurement: The maximum opening of the mouth will be checked by measuring the distance between the incisal edge of the central teeth with a ruler. Pain after wisdom tooth surgery. Timepoint: before surgery, 2 days, and 7 days after surgery. Method of measurement: visual analogue scale (VAS) will be used to measure pain. In addition, the number of pills used is also effective in measuring the pain level of patients. Mazandaran University of Medical Sciences Approved 2023-03-14 Ethics committee of Mazandaran University of Medical Sciences Moallem avenue Sari Mazandaran Iran (Islamic Republic of)