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IRCT20130812014333N207 IRCT 2023-08-20 Kermanshah University of Medical Sciences Investigating the effect of human menopausal gonadotropin and human chorionic gonadotropin treatment on testicular biopsy results Investigating the effect of human menopausal gonadotropin and human chorionic gonadotropin treatment on testicular biopsy results in Klinefelter patients. 2023-09-01 anticipated 44 Complete https://irct.ir/trial/71823 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using a simple random method. To hide the random allocation, the method of closed envelopes with random sequence (SNOSE) will be used, a number of envelopes, preparation and each of the created random sequences will be recorded on a card and the cards will be placed in the letter envelopes in order. In order to preserve the random sequence, the outer surface of the envelopes is numbered in the same order. Finally, the lid of the letter envelopes is glued, and it is placed inside the boxes in order. At the time of starting the registration of the participants, according to the order of entry of the eligible participants to the study, one of the letter envelopes will be opened and the assigned group of that participant will be revealed. 2-3 Male Infertility. Intervention 1: In the intervention group, HCG ampoules with a dose of 5000 units and HMG ampoules with a dose of 75 units are prescribed twice a week by intramuscular injection for 6 weeks. Intervention 2: No medicine is prescribed in the control group. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Dr. Behrouz Rostami
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 Behrouzrostami1368@yahoo.com Kermanshah University of Medical Sciences scientific Dr. Hossein Abdi
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 abdihossein96@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Informed consent Age between 18 and 65 years Diagnosis of azoospermia based on semen analysis and urologist diagnosis Married patients 18 years 65 years Male Any genetic disease other than Klinefelter that is associated with infertility Presence of any concomitant disease that leads to infertility, such as varicocele A history of infertility for any reason in the patient's wife The patient's single testicle N46.1 Oligospermia Treatment - Drugs Other In the intervention group, HCG ampoules with a dose of 5000 units and HMG ampoules with a dose of 75 units are prescribed twice a week by intramuscular injection for 6 weeks. No medicine is prescribed in the control group. Presence and absence of sperm. Timepoint: The beginning of the study and the end of the study (6 weeks after the start of treatment). Method of measurement: Sperm test. Kermanshah University of Medical Sciences Approved 2023-03-12 Ethics committee of Kermanshah University of Medical Sciences Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences, Building No.2, Shahid Beheshti Boulevard Kermanshah Kermanshah Iran (Islamic Republic of)