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IRCT20230806059062N1 IRCT 2023-08-20 Ahvaz University of Medical Sciences Effect of Dapsone gel 5% in the treatment of patients with acne vulgaris Comparative evaluation of Dapsone gel 5% with Adapalene gel 0.1% in patients with acne vulgaris 2023-09-23 anticipated 60 Complete https://irct.ir/trial/71828 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with eligibility criteria will be divided into two groups using a randomized block design. An online website (https://www.sealedenvelope.com) is used to generate a random list based on the desired sample size and block size of 4. After creating a list, each patient will identify with a unique code throughout the study. 30 people are selected for the first intervention group and 30 people for the second intervention group. Then, each number is written on the drug container, which is the same for both groups, and it will be given to the patients by someone other than the interventionist, while the patients are not aware of the contents of the container, Blinding description: Patients will be evaluated by another specialist as part of the main researcher, and the design will be done in a double-blind manner. Medicines are provided to patients in a sealed container by a non-interventionist who is the same for both groups, so that patients will not know about its contents due to the similarity of the two types of gel. 3 Acne. Intervention 1: Intervention group: Treatment with 5% dapsone gel (Pars Behrouzan Jam Company) twice a day for 2 months. Intervention 2: Intervention group: Treatment with Adapalene gel 0.1 % (Razak Company) twice a day for 2 months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Kosar Gholipour
Azadegan St. - Imam Khomeini Hospital
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 3314 0000 gholipour.k@ajums.ac.ir Ahvaz University of Medical Sciences scientific Kosar Gholipour
Azadegan St. - Imam Khomeini Hospital
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 3314 0000 gholipour.k@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Patients with moderate to severe inflammatory acne on the face 12 years 30 years Both Pregnant and lactating women History of using systemic anti-acne treatment drugs in the previous 1 month The presence of inflammatory acne on the trunk without facial involvement Cases of mild acne (the presence of only comedones without inflammatory lesions) Photosensitivity Patients receiving drugs that cause photosensitivity (such as griseofulvin). Age above 30 years and below 12 years Patients with G6pd deficiency (in the group receiving dapsone gel) History of allergy to doxycycline, adapalene and dapsone L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: Treatment with 5% dapsone gel (Pars Behrouzan Jam Company) twice a day for 2 months Intervention group: Treatment with Adapalene gel 0.1 % (Razak Company) twice a day for 2 months Acne severity based on the global acne grading system. Timepoint: Before starting treatment, 1, 2 and 3 months after starting treatment. Method of measurement: Global acne grading system. Ahvaz University of Medical Sciences Approved 2023-05-09 Ethics committee of Golestan Hospital Ahvaz Jundishapur University of Medical Sciences Golestan blvd- Golestan Hospital Ahvaz Khouzestan Iran (Islamic Republic of)