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IRCT20191025045235N1 IRCT 2023-08-22 Ahvaz University of Medical Sciences the effect of dexamethasone on nausea and vomiting The effect of dexamethasone in control of postoperative nausea and vomiting in cesarean section surgery 2023-03-21 anticipated 60 Complete https://irct.ir/trial/72043 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: People were divided into two groups completely randomly based on the random block permutation method. For example, for blocks of four, we imagined 6 blocks ABBA, AABB, ABAB, BABA, BBAA, BAAB, which should be n/4 We sampled from these blocks in the form of placement. The random sequence was obtained from the website www.sealedenevelope.com. Patients are entered in the order of entry, Blinding description: the patient and the anesthesia technician are unware of the type of injected drug.the medicine is already prepare and given to the technician. 3 vomiting. Intervention 1: Intervention group: Dexamethasone group, including 30 people, will be injected before surgery for the purpose of PONV prophylaxis by a trained anesthesiologist who will be unaware of the type of drug injected, then the patients will be under spinal anesthesia with a 25-gauge spinal needle in the L4 space. L5 with 12.5 mg marcaine. During the surgery, the frequency of nausea, vomiting and shivering, blood pressure, and heart rate will be recorded by him, and after the operation, these parameters will be recorded in the ward at 1, 2, 4, 6, and 12 hours. and vomiting, through the V&N scoring table. The patient's shivering score is also recorded. Intervention 2: Control group: before surgery, normal saline group including 30 people will be injected for prophylaxis of PONV by a trained anesthesiologist, who will be unaware of the type of drug injected, then the patients will be under spinal anesthesia with a 25 gage spinal needle in the L4 space. - L5 with 5.12 mg marcaine. During the surgery, the frequency of nausea, vomiting and shivering, blood pressure, and heart rate will be recorded by him, and after the operation, these parameters will be recorded in the ward at 1, 2, 4, 6, and 12 hours. and vomiting, through the V&N scoring table. The patient's shivering score is also recorded. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after de-identifying individuals When: The access period starts 6 months after the results are published To whom: It will be available for researchers working in academic and scientific institutions Conditions: Age, hemodynamics of the patient. The degree of response to the drug Where to obtain: Through the published article How to obtain: Email a request or receive information from a published article Comments:
public Seyedeh Fatemeh Hosseininejad
Emam Khomeini Hospital,Azadegan Street , Ahwaz
Ahwaz Iran (Islamic Republic of) 6155883505 009833113861 drhosseininejad@yahoo.com Ahvaz University of Medical Sciences scientific Seyedeh Fatemeh Hosseininejad
Emam Khomeini Hospital,Azadegan Street, Ahwaz
Ahwaz Iran (Islamic Republic of) 6155883505 009833113861 drhosseininejad@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) pregnant womanwith cesarean section indication age between 18 and 40 consent to participate in the study ASA class 1,ASA class 2 no history of heart disease 18 years 40 years Female patient dissatisfaction numbness above T4 HTN before pregnancy ,preeclampsia,eclampsia drug allergy a bleeding process that leads to generalization of the patient R11.1 Vomiting Treatment - Drugs Placebo Intervention group: Dexamethasone group, including 30 people, will be injected before surgery for the purpose of PONV prophylaxis by a trained anesthesiologist who will be unaware of the type of drug injected, then the patients will be under spinal anesthesia with a 25-gauge spinal needle in the L4 space. L5 with 12.5 mg marcaine. During the surgery, the frequency of nausea, vomiting and shivering, blood pressure, and heart rate will be recorded by him, and after the operation, these parameters will be recorded in the ward at 1, 2, 4, 6, and 12 hours. and vomiting, through the V&N scoring table. The patient's shivering score is also recorded Control group: before surgery, normal saline group including 30 people will be injected for prophylaxis of PONV by a trained anesthesiologist, who will be unaware of the type of drug injected, then the patients will be under spinal anesthesia with a 25 gage spinal needle in the L4 space. - L5 with 5.12 mg marcaine. During the surgery, the frequency of nausea, vomiting and shivering, blood pressure, and heart rate will be recorded by him, and after the operation, these parameters will be recorded in the ward at 1, 2, 4, 6, and 12 hours. and vomiting, through the V&N scoring table. The patient's shivering score is also recorded Severe nausea and vomiting after surgery. Timepoint: 1,2,4,6,12hours after surgery. Method of measurement: V&N score table. Jundishapur University of Ahvaz Approved 2023-03-21 Ethics committee of Jondishapoor Ahvaz University of Medical Sciences EmamKhomeini Hospital,Azadegan Street,Ahvaz Ahwaz Khouzestan Iran (Islamic Republic of)