IRCT201106146804N1 IRCT 2011-12-17 Vice Chancellor for research , Baghyatallah Medical Sciences University. Assessment of efficacy and complication of morphine and naloxan in renal colic Comparative assessment of analgesic and complications of intravenous morphine and placebo with intravenous naloxon and morphine in renal colic patients 2011-12-10 anticipated 300 Complete https://irct.ir/trial/7223 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. 2-3 Renal colic. Intervention 1: 150 renal colic patients in group B (intervention group), with 18-69 years old age and Pain score, equal or more than 40 or 4 in VAS or NRS system, respectively, will receive 1 CC of low dose naloxone (0.04 mg) intravenously in similar syringes. 5 minutes later,this group will receive 2.5 mg morphine sulfate intravenously. Then we will fallow the patients according to their pain score and complications every 15 minutes for about 90 min. If the pain score does not diminish below 4, we will administer other doses of morphine (max dose: 10 milligram). If despite the Morphine administration (max dose: 10 mg), pain score remains more than the mentioned threshold, the patient will exclude from the study but his pain management will continue. Intervention 2: 150 renal colic patients in Group A (control group); with 18-69 years old age and Pain score, equal or more than 40 or 4 in VAS or NRS system, respectively, will receive 1 cc saline as placebo intravenously. 5 minutes later,this group will receive 2.5 mg morphine sulfate intravenously. Then we will fallow the patients according to their pain score and complications every 15 minutes for about 90 min. If the pain score does not diminish below 4, we will administer other doses of morphine (max dose: 10 milligram). If despite the Morphine administration (max dose: 10 mg), pain score remains more than the mentioned threshold, the patient will exclude from the study but his pain management will continue.