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IRCT20230825059254N1 IRCT 2023-09-30 Tehran University of Medical Sciences Investigating the appropriate dose of sodium thiopental for induction of anesthesia Investigating the appropriate dose of sodium thiopental for induction of anesthesia in patients with BMI greater than 25 who undergo surgery with tracheal intubation 2023-10-23 anticipated 90 Complete https://irct.ir/trial/72281 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Due to the existence of three groups of thirty members in the study, 6 blocks of three were created: 1. ABC 2. ACB 3. BAC 4. BCA 5. CAB 6. CBA A: Sodium thiopental is injected to the patient based on total body weight. B: Based on ideal body weight, sodium thiopental is injected to the patient. C: Based on adjusted body mass, sodium thiopental is injected to the patient. Using Excel software, a random number between 0 and 9 is created. The block corresponding to each number indicates on what basis each patient receives sodium thiopental. To reach a sample size of 90 (30 people in each group), this work is repeated 30 times. Random numbers zero, 7, 8 and 9 are ignored, Blinding description: Patients were unaware of which study group they were in. 3 Appropriate dose of sodium thiopental for induction of anesthesia. Intervention 1: Intervention group: In the first intervention group, sodium thiopental was calculated and injected based on total body weight to induce anesthesia. Intervention 2: Intervention group: In the second intervention group, sodium thiopental was calculated and injected based on ideal body weight to induce anesthesia. Intervention 3: Intervention group: In the third intervention group, sodium thiopental was calculated and injected based on adjusted body mass to induce anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Amirhossein Farhadi
Imam Khomeini hospital complex, Qarib St., Keshavarz Blvd.
Tehran Iran (Islamic Republic of) ۱۴۱۹۷۳۳۱۴۱ 0098 21 61190 am.farhady@gmail.com Tehran University of Medical Sciences scientific Amirhossein Farhadi
Imam khomeini hospital complex, Qarib St., Keshavarz Blvd.
Tehran Iran (Islamic Republic of) ۱۴۱۹۷۳۳۱۴۱ 0098 21 61190 am.farhady@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) ASA Class I and II ASA Class III if it is due to BMI more than 40 BMI more than 25 obtaining informed consent 20 years 60 years Both Patients with age less than 20 years or more than 60 years Discontentment with the project ASA Class IV and V Patients with unstable hemodynamics, hemorrhagic shock and heart failure Recent abuse of morphine or any other drugs Patients with porphyria, asthma, uncontrolled hypertension and hypothyroidism Patients with lowering of consciousness Patients with drug allergies Patients requiring second laryngoscopy or failed intubation Other Other Other Intervention group: In the first intervention group, sodium thiopental was calculated and injected based on total body weight to induce anesthesia. Intervention group: In the second intervention group, sodium thiopental was calculated and injected based on ideal body weight to induce anesthesia. Intervention group: In the third intervention group, sodium thiopental was calculated and injected based on adjusted body mass to induce anesthesia. Bispectral Index. Timepoint: Before induction of anesthesia, after injection of sodium thiopental, three minutes after induction of anesthesia. Method of measurement: BIS monitoring. Heart Rate. Timepoint: Before induction of anesthesia, after injection of sodium thiopental, three minutes after induction of anesthesia. Method of measurement: Pulse oximetry. Mean Arterial pressure. Timepoint: Before induction of anesthesia, after injection of sodium thiopental, three minutes after induction of anesthesia. Method of measurement: NIBP monitoring. Tehran University of Medical Sciences Approved 2023-07-19 Ethics committee of Tehran University of Medical Sciences Keshavarz blvd. Tehran Tehran Iran (Islamic Republic of)