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IRCT20230828059283N1 IRCT 2023-08-29 Karaj University of Medical Sciences Investigating the effectiveness of gases impregnated with diluted hydrogen peroxide and tranexamic acid in bleeding control and its clinical application on aspirin consuming patients. Comprasion of the Effect of dilute hydrogen peroxide and tranexamic acid with local application of gas on control of bleeding after tooth extraction in patients using asprin 2023-09-23 anticipated 24 Complete https://irct.ir/trial/72302 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: The surgeon and the patient will not know the type of medicine used. 3 Comprasion of the effect of dilute hydrogen peroxide and tranexamic acid with local application of gas on control of bleeding after tooth extraction in patients using asprin. Intervention 1: Intervention group: In the desired group 1, two gauzes soaked in 10 ml of diluted hydrogen peroxide solution (1%) prepared by the pharmacy technician (by adding 3.3 ml of water with 6.6 ml of 1.5% hydrogen peroxide) is kept in place for10 and 15 minutes immediately after tooth extraction. Intervention 2: Intervention group: In the target group 2, two gauzes impregnated with tranexamic acid solution after tooth extraction in the form of 10 ml tranexamic acid solution and two ampoules of tranexamic acid 50 mg/5 ml with a concentration of 4.8% immediately after tooth extraction for It is kept in place for 10 to 15 minutes. Intervention 3: Control group: control group: . In the control group, after tooth extraction, without using any local coagulant, the patient is asked to keep the two gauzes in place for 10 and 15 minutes using two sterile gauzes. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public RAZIYEH Taheri
Shahid Katoiizade St, 45 meters Golshahr, Karaj
karaj Iran (Islamic Republic of) 3198684868 +98 26 3350 0080 sarataheri196@yahoo.com Karaj University of Medical Sciences scientific RAZIYEH Taheri
Shahid Katoiizade St, 45 meters Golshahr, Karaj
Karaj Iran (Islamic Republic of) 3198684868 +98 26 3355 5049 sarataher196@yahoo.com Karaj University of Medical Sciences Iran (Islamic Republic of) Teeth with deep decay and teeth that are extracted due to periodontal reasons and removed non-surgically. Patients without other systemic diseases and non-smokers. no limit no limit Both Patients with systemic diseases and the use of anticoagulant drugs except aspirin and smokers, teeth with periodontal problems and the need for open surgery during treatment. Unknown internal coagulation disorders factors Qualitative and quantitative platelet problems Taking other anticoagulant drugs by the patient History of hemophilia Patients using aspirin more than 80 mg Treatment - Drugs Treatment - Drugs N/A Intervention group: In the desired group 1, two gauzes soaked in 10 ml of diluted hydrogen peroxide solution (1%) prepared by the pharmacy technician (by adding 3.3 ml of water with 6.6 ml of 1.5% hydrogen peroxide) is kept in place for10 and 15 minutes immediately after tooth extraction Intervention group: In the target group 2, two gauzes impregnated with tranexamic acid solution after tooth extraction in the form of 10 ml tranexamic acid solution and two ampoules of tranexamic acid 50 mg/5 ml with a concentration of 4.8% immediately after tooth extraction for It is kept in place for 10 to 15 minutes Control group: control group: . In the control group, after tooth extraction, without using any local coagulant, the patient is asked to keep the two gauzes in place for 10 and 15 minutes using two sterile gauzes. Active bleeding:Bleeding refers to bleeding that does not form a clot after a period of 2 to 9 minutes and is continuous. Timepoint: 10 to 15 minute. Method of measurement: Clinical examinations. The cost is covered by the student Approved 2023-08-12 Ethics committee of Alborz University of Medical Sciences Safarian Alley, 45 meters from Golshahr, Karaj karaj Alborz Iran (Islamic Republic of)