IRCT20230828059288N1 IRCT 2023-08-30 Qazvin University of Medical Sciences Investigating the effect of high dose vitamin C on preventing anastomotic leakage after colon anastomosis surgery Investigating the effect of high dose ascorbic acid on preventing anastomotic leakage after colon anastomosis surgery: a randomized clinical trial study 2023-09-11 anticipated 88 Complete https://irct.ir/trial/72307 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: The method of random allocation in this study is Balanced Block Randomization. 6 blocks AABB- ABAB_ ABBA- BBAA- BABA_ BAAB are numbered based on 1 to 6 and numbers 1 to 6 are selected from the table of random numbers and placed together. Then they are replaced with numbered blocks, Blinding description: The surgical resident receives the drugs which are coded in closed envelopes and injects them into the patients. Coding is done by one of the colleagues of the project and the doctor, surgical resident, and patient are blinded. 2 Anastomotic leakage. Intervention 1: Intervention group: Injection of 10 mg of ascorbic acid with a concentration of 1000 as a single dose and daily starting 12 hours after colorectal anastomosis surgery for five days; product in the form of two ampoules of vitamin C with a concentration of 500 mg and a volume of 5 ml It is prepared from Osweh Pharmaceutical Company. Intervention 2: Control group: Injection of 10 mg of distilled water. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information