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IRCT20230828059290N2 IRCT 2023-09-12 Khoram-Abad University of Medical Sciences The effect of sports activity on bones The effect of 12 weeks of resistance training with different muscle tensions on mir-92, mir-204, mir-214, mir-233 and sclerostin in elderly women 2023-09-23 anticipated 15 Complete https://irct.ir/trial/72316 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: It is block randomization. In order to perform block randomization, a specific code is assigned to each of the people under study (66 people). Then, blocks with a volume of 6 people, which have 3 exclusive codes, are defined. Two A codes, two B codes, and two C codes are identified. Each of these three codes represent each of the groups under study. From the combination and sequence of these codes in blocks of 6, different blocks are created. Then, using Stata software version 17 and using the command code egen block, blocks of 6 are selected by simple random method with placement. 11 blocks are selected using simple random placement method. N/A The subject of study is not a disease. Intervention 1: Intervention group: Intervention group: In this research, according to the training protocol, there are two intervention groups. In the first group, the resistance training protocol is in the form of three periods of 12 repetitions with 75% of a maximum repetition and with two-minute rests between periods, with a duration of one second of muscle tension. (one second of flexion and one second of extension) and in the second group in the form of three periods of three repetitions with 50% of a maximum repetition and with two-minute rests between periods, with a duration of six seconds of muscle tension (six seconds of flexion and six seconds of extension). Was performed. Intervention 2: Control group: Control group: In this research, there is a control group and they will not do any regular physical activity or exercise during the implementation of the protocol. Yes - There is a plan to make this available What will be shared: The information is confidential and the results will be published as an article When: It does not have a specific yield To whom: Only the research team is allowed to access the data Conditions: It is for the purpose of analyzing information. Where to obtain: The documents are only available to the research team How to obtain: The documents are only available to the research team Comments:
public Fazlollah Fathollahi Shoorabeh
Kilometer 4, Borujerd Road, Medical Sciences Complex, Faculty of Medicine
Khormabad Iran (Islamic Republic of) 1478523698 +98 66 3342 5492 f.fathollahi1363@gmail.com Khoram-Abad University of Medical Sciences scientific Fazlollah Fathollahi Shorabeh
Kilometer 4, Borujerd Road, Medical Sciences Complex, Faculty of Medicine
Khoramabad Iran (Islamic Republic of) 1478523695 +98 66 3342 5492 f.fathollahi1363@gmail.com Khoram-Abad University of Medical Sciences Iran (Islamic Republic of) No surgery Not having any heart disease Not smoking and drinking alcohol Not having a physical problem such as orthopedic and brain-nervous problems that prevent exercise. Blood pressure > 110/180 as a criterion for exiting the study process Menopause Age range in the specified age range of 45 to 65 45 years 65 years Female Lack of continuous exercise before starting the training program Inability to exercise ICD-10 Diagnosis N/A Intervention group: Intervention group: In this research, according to the training protocol, there are two intervention groups. In the first group, the resistance training protocol is in the form of three periods of 12 repetitions with 75% of a maximum repetition and with two-minute rests between periods, with a duration of one second of muscle tension. (one second of flexion and one second of extension) and in the second group in the form of three periods of three repetitions with 50% of a maximum repetition and with two-minute rests between periods, with a duration of six seconds of muscle tension (six seconds of flexion and six seconds of extension). Was performed. Control group: Control group: In this research, there is a control group and they will not do any regular physical activity or exercise during the implementation of the protocol. Increased serum sclerostin levels. Timepoint: 48 hours before and after the last training session. Method of measurement: blood test. Decreased serum mir-92 levels. Timepoint: 48 hours before and after the last training session. Method of measurement: blood test. Increased serum mir-214 levels. Timepoint: 48 hours before and after the last training session. Method of measurement: blood test. Decreased serum mir-233 levels. Timepoint: 48 hours before and after the last training session. Method of measurement: blood test. Noblood pressure. Timepoint: 48 hours before and after the implementation of the research protocol. Method of measurement: nothrough a blood pressure monitor. Khoram-Abad University of Medical Sciences Approved 2023-08-09 Research Ethics Committees of Lorestan University of Medical Sciences km 4, Borujerd Road, Vice-Chancellor of Research and Technology, Lorestan University of Medical Sciences Khorram Abad Lorestan Iran (Islamic Republic of)