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IRCT20091012002576N32 IRCT 2023-09-05 Tehran University of Medical Sciences Intraovarian PRP & Gh in poor ovarian responder The effects of intraovarian platelet rich plasma and growth hormone injection on infertile women with poor ovarian response 2023-09-23 anticipated 60 Complete https://irct.ir/trial/72321 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Female infertility of other origin. Intervention 1: Intervention group: Gh and platelet reach plasma that is prepared from patient's peripheral blood and injected in the ovarian tissue by transvaginal ultrasonographic guidance at the day of oocyte punctuer under anesthesia after three months, ovarian function will be compared with pervious cycle. Intervention 2: Control group: pervious cycle of each patient which oocyte punctuer was performed. Yes - There is a plan to make this available What will be shared: IPD collected for the primary outcome measure only. When: After publishing article To whom: Academic researchers Conditions: After presenting approved proposal, unidentified patients data available for statically analysis. Where to obtain: Dr.Davari,Fatedavtanha@gmail.com How to obtain: Request by email Comments:
public Fatemeh Davari Tanha
North Nejatollahi Avenue, Karim khan Zand Bridge, Villa Street
Tehran Iran (Islamic Republic of) 159781597815 +98 21 8880 0115 Fatedavtanha@gmail.com Tehran University of Medical Sciences scientific Fatemeh Davari Tanha
North Nejatollahi Avenue, Karim khan Zand Bridge, Villa Street
Tehran Iran (Islamic Republic of) 159781597815 +98 21 8880 0115 Fatedavtanha@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Age 20-40 years old with abnormal ovarian reserve test. Antral follicle count<5. At least one previous IVF cycle <3oocyte was retrieved. 20 years 40 years Female Ovarian insufficiency due to gonadal dysgenesia and abnormality of chromosoms Male infertility N97.8 Female infertility of other origin Treatment - Surgery Treatment - Surgery Intervention group: Gh and platelet reach plasma that is prepared from patient's peripheral blood and injected in the ovarian tissue by transvaginal ultrasonographic guidance at the day of oocyte punctuer under anesthesia after three months, ovarian function will be compared with pervious cycle. Control group: pervious cycle of each patient which oocyte punctuer was performed. Chemical pregnancy. Timepoint: Two weeks after fetal transfer. Method of measurement: Beta HCG test. AMH. Timepoint: before and 3 months after intervention. Method of measurement: Measurements blood levels of AMH by Eliza method. Clinical pregnancy. Timepoint: Four weeks after embryo transfer. Method of measurement: Heart beat activity in transvaginal sonogram. Tehran University of Medical Sciences Approved 2023-08-30 Ethic committee of Tehran University of medical sciences Deputy of Research, sixth floor of central building of Tehran University of medical sciences, Ghods Avenue, Keshavarz Blvd. Tehran Tehran Iran (Islamic Republic of)