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IRCT20180811040759N5 IRCT 2023-10-24 Rafsanjan University of Medical Sciences The effects of alendronate on the function and pain in patients with knee osteoarthritis referred to Rheumatology Clinic The effects of alendronate on the function and pain in patients with knee osteoarthritis referred to Rheumatology Clinic 2023-10-07 anticipated 80 Complete https://irct.ir/trial/72364 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization method. Unit: individual, simple randomization tool: first, stewartritis patients were randomly selected from among the clients to the clinic according to clinical evidence and randomly divided into two groups: control group and alendronate group without regard to gender. It should be noted that there were 40 people in the control group and 40 people in the Alendronite group.people. 3 Osteoarthritis. Intervention 1: Intervention group: Group 1 (40 people) will use alendronite. The duration of treatment will be 2 months, 70 mg will be administered orally weekly. Intervention 2: Control group: Group 2 (Placebo) (40 individuals). The form and type of the drug is the same. The treatment duration is 2 months, 70 mg will be administered orally weekly. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It is not yet known if there will be a plan to make this available
public Mahsa Hassanipour
Central Organization of Rafsanjan University of Medical Sciences. Imam Ali Avenue, Rafsanjan
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0040 mahsahasanipour@rums.ac.ir Rafsanjan University of Medical Sciences scientific Mahsa Hassanipour
Central Organization of Rafsanjan University of Medical Sciences. Imam Ali Avenue, Rafsanjan
Rafsanjan Iran (Islamic Republic of) 7717933777 +98 34 3428 0040 mahsahasanipour@rums.ac.ir Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Age 45-70 years The diagnosis of osteoarthritis of the knee according to the criteria of the American College of Rheumatology, which is confirmed by a specialist in hematology 45 years 70 years Both Patients suffering from inflammatory diseases (such as lupus, rheumatoid arthritis, history of brucellosis, etc.) Cancer with serious diseases Symptoms with a history of liver or kidney failure Oral corticosteroid use in the last 4 weeks Cortisone injection in the last 6 months Fever Consuming medicinal plants continuously Unwillingness to continue participating in the study Use of dietary and medicinal supplements Consuming painkillers on a regular daily basis and very advanced disease M17 Osteoarthritis of knee Treatment - Drugs Placebo Intervention group: Group 1 (40 people) will use alendronite. The duration of treatment will be 2 months, 70 mg will be administered orally weekly. Control group: Group 2 (Placebo) (40 individuals). The form and type of the drug is the same. The treatment duration is 2 months, 70 mg will be administered orally weekly. Knee pain intensity. Timepoint: At the beginning and the end of the study (two months after the beginning of the study). Method of measurement: Visual Analogue Scale (VAS) And WOMAC index. Rafsanjan University of Medical Sciences Approved 2021-04-05 Ethics Committee of Rafsanjan University of Medical Sciences Ali ibn Abi Talib Square, Ali ibn Abi Talib Hospital Rafsanjan Kerman Iran (Islamic Republic of)