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IRCT20110522006543N4 IRCT 2023-09-07 Ahvaz University of Medical Sciences Investigating the safety and effectiveness of platelet-rich plasma with 5% minoxidil solution in the treatment of androgenic hair loss. A comparative study of the effect of platelet-rich plasma injection with 5% minoxidil solution versus 5% minoxidil solution in the treatment of androgenetic hair loss 2023-09-23 anticipated 40 Complete https://irct.ir/trial/72379 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with eligibility criteria will be divided into two groups using a randomized block design. An online website (https://www.sealedenvelope.com) is used to generate a random list based on the desired sample size and block size of 4. After creating a list, each patient will be identified with a unique code throughout the study. 20 people are selected for the first intervention group and 20 people for the second intervention group. Then, each number is written on the drug container, which is the same for both groups, and it will be given to the patients by someone other than the interventionist, while the patients are not aware of the contents of the container, Blinding description: In this study, the participant, researcher, doctor, interventionist and evaluator will be unaware of the type of drug until the end of the study. The composition of this medicine is poured into similar containers and they cannot be distinguished from each other in terms of color and smell. 2 Androgenic hair loss. Intervention 1: Intervention group: Injection of platelet-rich plasma with 5% minoxidil solution for 4 weeks, 0.1 cc per centimeter for 3 months. Intervention 2: Intervention group: 5% minoxidil solution for 3 months by the patient locally. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Fateme Tajbakhsh
Golestan
Ahvaz Iran (Islamic Republic of) 6135715794 +98 903 026 8698 tajbakhsh.f@ajums.ac.ir Ahvaz University of Medical Sciences scientific Fateme Tajbakhsh
Golestan
Ahvaz Iran (Islamic Republic of) 6135715794 +98 903 026 8698 tajbakhsh.f@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Men with hereditary hormonal hair loss Age 18 years and above and less than 50 years The rate of hair loss in patients in the form of Hamilton score 2 to 5 in men Complete consent of the patient to participate in the plan 18 years 50 years Male Having a hematological disorder Iron deficiency anemia Having coagulation disorders Bone marrow aplasia Suffering from sepsis Having cancer L64.9 Androgenic alopecia, unspecified Treatment - Other Treatment - Other Intervention group: Injection of platelet-rich plasma with 5% minoxidil solution for 4 weeks, 0.1 cc per centimeter for 3 months. Intervention group: 5% minoxidil solution for 3 months by the patient locally Photography before and after treatment of the hair loss area. Timepoint: Before starting the intervention, each treatment session is monthly for 4 months and also 6 months after the end of the treatment. Method of measurement: Photography with a camera. Safety. Timepoint: Before starting the intervention, each treatment session is monthly for 4 months and also 6 months after the end of the treatment. Method of measurement: Doctor's assessment of hair loss, history. Efficacy. Timepoint: Before starting the intervention, each treatment session is monthly for 4 months and also 6 months after the end of the treatment. Method of measurement: Doctor's assessment of hair loss, patient's satisfaction, history. Side effects. Timepoint: At the beginning of the intervention, monthly for 4 months, once every month, after 6 months. Method of measurement: Observation. Ahvaz University of Medical Sciences Approved 2023-07-11 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Golestan Ahvaz Khouzestan Iran (Islamic Republic of)