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IRCT20190618043934N21 IRCT 2023-09-27 Birjand University of Medical Sciences The effect of alpha-ipoic acid supplementation along with neuromuscular training in the recovery of multiple sclerosis The effect of combination of Alphalipoic acid and neuromuscular exercises on electrical activity of affected muscles in patients with multiple sclerosis. 2023-10-07 anticipated 12 Complete https://irct.ir/trial/72601 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Placement of people in each group randomly in one of three groups including: the first group receiving alpha lipoic acid supplement for 2 months in the form of 300 mg tablets twice a day (morning and night) (A), the second group receiving The recipient of neuromuscular training in a period of 8 weeks (3 days per week) will be divided into 18 training stations in a circle including static and dynamic exercises (B) and the third group receiving supplement + neuromuscular training (C). Then, first, various triple blocks (ABC, ACB, BAC, BCA, CAB, CBA) are created on different cards. One of these blocks will be randomly selected using the lottery method and the patients will be divided into one of three groups A, B or C. Then randomization is done for other patients as well. This will be done by the secretary, Blinding description: Outcome evaluator: The study administrator will perform the necessary evaluation without knowing the type of intervention received by the patients and will be recorded in the checklist that was designed for this purpose. 3 Multiple sclerosis. Intervention 1: Intervention group: Intervention group 1: The receiving group received alpha lipoic acid supplement in the form of 300 mg tablets twice a day (morning and night) for 2 months. Intervention 2: Intervention group: Intervention group 2: The recipient of neuromuscular training will perform 18 training stations in a circle including static and dynamic exercises in a period of 8 weeks (3 days per week). Intervention 3: Intervention group: Intervention group 3: receiving supplement + neuromuscular training for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no need to publish individual patient information
public Zabihullah Mohaqiq
School of Medicine, Birjand University of medical sciences, Ghahhari Blvd, Birjand Town
Birjand Iran (Islamic Republic of) 9717934888 +98 56 3232 3232 zabihullahmohaghegh@gmail.com Birjand University of Medical Sciences scientific Dr Mohammad Mousavi mirzaie
Department of Neurology, School of Medicine, Birjand University of medical sciences, Ghahhari Blvd, Birjand Town
Birjand Iran (Islamic Republic of) 9717811674 +98 56 3232 3232 mousavim903@mums.ac.ir Birjand University of Medical Sciences Iran (Islamic Republic of) Relapsing and recovering MS patients with severe disease activity who are treated with rituximab patients with disability grade 4.5 to 6 Patients who are able to walk without assistance Patients who can walk at least 100 meters Age between 20 and 45 years 20 years 45 years Both Unwillingness of patients to cooperate with the research team Absence of more than 3 sessions in practice sessions Not taking alpha lipoic acid medicine regularly Failure to answer the phone call to continue the treatment G35 Multiple sclerosis Treatment - Drugs Treatment - Other Treatment - Drugs Intervention group: Intervention group 1: The receiving group received alpha lipoic acid supplement in the form of 300 mg tablets twice a day (morning and night) for 2 months. Intervention group: Intervention group 2: The recipient of neuromuscular training will perform 18 training stations in a circle including static and dynamic exercises in a period of 8 weeks (3 days per week). Intervention group: Intervention group 3: receiving supplement + neuromuscular training for 8 weeks. Average kinematic parameters of lower limb joints (three-dimensional angles of ankle, knee and thigh joints). Timepoint: At the beginning of the study and before the start of interventions related to each group and 2 months after the relevant interventions, a necessary evaluation is done. Method of measurement: The IMU device is used to check the three-dimensional angles of the ankle, knee and thigh joints. Average performance variables (7.5 meter walking, standing and timed walking tests). Timepoint: The IMU device is used to check the three-dimensional angles of the ankle, knee and thigh joints. Method of measurement: To evaluate the timed rise and walk test, the time taken for a person to stand up from a normal chair with a seat height of 45 cm (leaning on the back of the chair while the soles of his feet are on the floor and behind the marking line) Get up and walk a distance of three meters at your maximum safe speed and come back and sit back on the chair and lean back. It is recorded by a stopwatch. It is also used to evaluate the 7.5 meter walking test or the 25 foot test, a standard method to check the ability of patients to walk. MS is used by neurologists in such a way that patients are asked to cover a distance of 7.5 meters as quickly as possible, which usually should be done in less than 4 seconds in healthy people and patients who do not have significant mobility disabilities. Birjand University of Medical Sciences Approved 2022-11-07 Ethics Committee of Birjand University of Medical Sciences Vice Chancellor for Research and Technology, Birjand University of Medical Sciences, Ghaffari Blvd, Birjand Town Birjand South Khorasan Iran (Islamic Republic of)