IRCT20230912059416N1 IRCT 2023-11-11 Mashhad University of Medical Sciences the effect of perianal injection of dexmedetomidine compared to the effect of ketamine on the postoperative pain and vomiting of perianal fistula Investigating the effect of perianal injection of dexmedetomidine compared to the effect of ketamine on the postoperative pain and vomiting of perianal fistula: a triple-blind randomized clinical trial 2023-12-06 anticipated 102 Complete https://irct.ir/trial/72629 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The type of randomization is done using Excel software. The codes assigned to three groups will be written in the form of A, B, and C on separate sheets respectively. Each sheet is folded and glued. which cannot be seen inside. (Allocation concealment). After obtaining the patient's informed consent, a sheet will be removed with the entry of each qualified patient, and according to the code written in it, people will be placed in the three categories of dexmedetomidine or ketamine or the control group, Blinding description: Patients do not know the type of drug injected due to being unconscious, and because the drug is injected in the operating room, the researcher and evaluator will not know the type of drug injected. 3 Acute pain. Intervention 1: Control group: No medicine is injected subcutaneously in the perianal area after surgery. Intervention 2: Intervention group: In this group of patients, 1.5 micrograms/kg of dexmedetomidine diluted with a volume of 4 cc of distilled water is injected locally (subcutaneously) around the fistula by the surgeon. Intervention 3: Intervention group: In this group of patients, 0.5 mg/kg of ketamine diluted with 4 cc of distilled water is injected locally in the perianal area (subcutaneously). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information