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IRCT20171015036782N10 IRCT 2024-09-27 Yazd University of Medical Sciences Evaluation the effect of Simvastatin and platelets rich fibrin in the socket of extracted teeth. Comparison of the quality of formed bone and pain after use of platelet rich fibrin (PRF) and Simvastatin in the extracted tooth socket 2024-10-06 anticipated 19 Complete https://irct.ir/trial/72761 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of randomizing the samples is done using a table of random numbers. In order to hide the random allocation, the method of using a non-transparent sealed envelope is also used. In this way, two envelopes are prepared with aluminum fibers (in order to make the contents of the envelopes unclear) and each of the random intervention methods is recorded on a card and the cards are placed inside the envelopes in order. At the start of the intervention, based on the order of the intervention, one of the letter envelopes is opened and its assigned group is revealed, Blinding description: In this study, the participants will not be aware of the type of prescribed drug. 3 Loss of teeth due to accident, extraction or local periodontal disease. Intervention 1: Intervention group: Platelet-rich fibrin extracted from 40 cc of the patient's own blood, topically in extracted tooth socket.The blood extracted from the patient is immediately placed in a centrifuge and after separating the platelets rich fibrin (PRF) along with absorbable collagen, placed in the dental socket. Intervention 2: Intervention group: Simvastatin 20 mg manufactured by Tehran Chemical Company with the brand name Sivesterol 20, topically in extracted tooth socket. Simvastatin is powdered and then placed inside the socket of the extracted tooth by absorbable collagen. Yes - There is a plan to make this available What will be shared: Data sets used and/or analyzed during the present study are available from the corresponding author upon request. When: The access period starts 6 months after the results are published. To whom: Researchers working in academic and scientific institutions Conditions: Data sets used and/or analyzed during the present study are available from the corresponding author upon request. Where to obtain: In order to receive data/documents, you can contact the author of this study through the e-mail address faridf2171@gmail.com. How to obtain: By sending an email to the responsible author and explaining about the applicant's project proposal and how to use the information, the requested information will be available to the applicant after 10 days after approval by the responsible author. Comments:
public Faridoddin Fani
No.2,Second Alley, East touba Ave, Amirkabir Blvd ,Yazd
yazd Iran (Islamic Republic of) 8916147860 +98 35 3830 1323 faridf2171@gmail.com Yazd University of Medical Sciences scientific Faridoddin Fani
No.2,Second Alley, East touba Ave, Amirkabir Blvd ,Yazd
yazd Iran (Islamic Republic of) 8916147860 +98 35 3830 1323 faridf2171@gmail.com Yazd University of Medical Sciences Iran (Islamic Republic of) age between 20 to 65 years old candidate for implant insertion of both sides of a jaw two similar hopeless tooth of both sides of a jaw 20 years 65 years Both Pregnancy Smoking Using immunosuppressive medications Uncontrolled diabetes Systemic disease History of radiotherapy Allergy Periodontal disease K08.1 Complete loss of teeth Other Treatment - Drugs Intervention group: Platelet-rich fibrin extracted from 40 cc of the patient's own blood, topically in extracted tooth socket.The blood extracted from the patient is immediately placed in a centrifuge and after separating the platelets rich fibrin (PRF) along with absorbable collagen, placed in the dental socket. Intervention group: Simvastatin 20 mg manufactured by Tehran Chemical Company with the brand name Sivesterol 20, topically in extracted tooth socket. Simvastatin is powdered and then placed inside the socket of the extracted tooth by absorbable collagen. Percentage of vital bone. Timepoint: 3 months after tooth extraction at the time of the implant surgery, samples will be taken. Method of measurement: light microscope. Pain. Timepoint: 1 and 7 days after the extractions, pain will be measured. Method of measurement: Visual Analogue Scale. Non-vital bone. Timepoint: 3 months after tooth extraction at the time of the implant surgery, samples will be taken. Method of measurement: light microscope. Percentage of amorphous bone. Timepoint: 3 months after tooth extraction at the time of the implant surgery, samples will be taken. Method of measurement: light microscope. Percentage of trabecular bone. Timepoint: 3 months after tooth extraction at the time of the implant surgery, samples will be taken. Method of measurement: light microscope. Yazd University of Medical Sciences Approved 2023-07-31 Ethics committee of yazd University of Medical Sciences No.2,Second Alley, East touba Ave, Amirkabir Blvd ,Yazd Yazd Yazd Iran (Islamic Republic of)