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IRCT20220516054874N13 IRCT 2023-10-11 Mashhad University of Medical Sciences The effects of Ginger (Zinger offiicinale Roscoe) on the prevention of PVC in patients with palpitation The effects of Ginger (Zinger offiicinale Roscoe) on the prevention of PVC in patients with palpitation 2023-10-07 anticipated 48 Complete https://irct.ir/trial/72847 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The blocked randomization method is used. The volume of each block will be four. Then the list of blocks is written and numbers assigned to them, for example (AABB(1)- BBAA(2)- BABA(3)- BAAB(4)), which will be 12 blocks according to the sample size of 48. Then random numbers between 1 and 12 are selected according to the randomization site Randomaization.com and finally, the treatment allocation list is determined based on the random numbers, Blinding description: Blinding is done using sealed envelopes. Furthermore, due to using a placebo similar to the intervention treatment, the investigator and the participants will not be informed of the assigned treatment, and the analyst will also be unaware of the assigned treatment for the two groups. Finally, after analyzing the data, the researcher who prepared the packages will reveal the codes A and B. 2-3 Palpitations. Intervention 1: Intervention group: Patients with heart palpitations receiving capsule containing ginger rhizome powder at a dose of 250 mg once daily for 10 days. Intervention 2: Control group: Patients with heart palpitations receiving placebo capsule with similar shape, size, and color once daily for 10 days. The placebo capsule contains 250 mg of Avicel® and is prepared by Dr. Askari's research laboratory at Mashhad University of Medical Sciences. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available
public Dr. Vafa Baradaran Rahimi
Ghaeem hospital, Ahmadabad Blvd, Mashhad
Mashhad Iran (Islamic Republic of) 9177948564 0095 5138012739 baradaranrv@mums.ac.ir Mashhad University of Medical Sciences scientific Dr. Vafa Baradaran Rahimi
Ghaeem hospital, Ahmadabad Blvd, Mashhad
Mashhad Iran (Islamic Republic of) 9177948564 0095 5138012739 baradaranrv@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients with heart palpitations The number of PVCs during one day less than 15% in the 24-hour Holter rhythm Consent to admission to the study; 18 years no limit Both Previous history of heart palpitations History of receiving medications for PVC Structural heart disorder Stomach ulcers or duodenal ulcers Taking anticoagulants such as warfarin, aspirin and enoxaparin Breastfeeding or pregnancy Consumption of omega 3 (fish oil), ciprofloxacin, loratadine, citalopram, montelukast, and levothyroxine Kidney stone History of taking medicines containing ginger R00.2 Palpitations Treatment - Drugs Placebo Intervention group: Patients with heart palpitations receiving capsule containing ginger rhizome powder at a dose of 250 mg once daily for 10 days. Control group: Patients with heart palpitations receiving placebo capsule with similar shape, size, and color once daily for 10 days. The placebo capsule contains 250 mg of Avicel® and is prepared by Dr. Askari's research laboratory at Mashhad University of Medical Sciences. The number of PVCs during 24 h. Timepoint: Before intervention and 10 days after beginning the intervention. Method of measurement: 24-hour Holter rhythm. Mashhad University of Medical Sciences Approved 2023-04-10 Research Ethics Committee of Imam Reza Hospital Educational, Research and Treatment Center, Mashhad Imam Reza Hospital educational complex building, Imam Reza Hospital, Mashhad Mashhad Razavi Khorasan Iran (Islamic Republic of)